NDLI: Immunodominance among herpes simplex virus-specific CD8 T cells expressing a tissue-specific homing receptor.

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Immunodominance among herpes simplex virus-specific CD8 T cells expressing a tissue-specific homing receptor.

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Immunodominance among herpes simplex virus-specific CD8 T cells expressing a tissue-specific homing receptor.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Corey, Lawrence Vieira, Jeffrey Liu, Zhi Hosken, Nancy A. Snow, Devon C. Koelle, David M. Meseda, Clement A. Cevallos, Randal C. Mcclurkan, Christopher L. Wald, Anna
Description	Author Affiliation: Koelle DM ( Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA. viralimm@u.washington.edu);
Abstract	The study of immunodominance within microbe-specific CD8 T cell responses has been challenging. We used a previously undescribed approach to create unbiased panels of CD8 cytotoxic T lymphocyte clones specific for herpes simplex virus type 2, a pathogen with a complex genome encoding at least 85 polypeptides. Circulating herpes simplex virus type 2-specific cells were enriched and cloned after sorting for expression of the skin homing-associated receptor, cutaneous lymphocyte-associated antigen, bypassing restimulation with antigen. The specificity of the resultant cytotoxic clones was determined. Clonal frequencies were compared with each other and with the total number of cytotoxic clones. For each subject within the homing receptor-positive compartment, the CD8 cytotoxic response was dominated by T cells specific for only a few peptides. Previously undescribed antigens and epitopes in viral tegument, capsid, or scaffold proteins were immunodominant in some subjects. Clone enumeration analyses were confirmed in some subjects with dominance studies by using herpes simplex mutants, vaccinia recombinants, and/or enzyme-linked immune spots. We conclude that among circulating cells expressing a homing-associated receptor, during chronic herpes type 2 infection, the CD8 T cell response becomes quite focused despite the presence of many potential antigenic peptides.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	22
Volume Number	100
Language	English
Publisher	National Academy of Sciences
Publisher Date	2003-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	CD8-Positive T-Lymphocytes Immunology Herpesvirus 2, Human Immunodominant Epitopes Receptors, Lymphocyte Homing Antigens, CD Cell Line, Transformed Cells, Cultured Cytotoxicity, Immunologic HLA-A Antigens Herpes Simplex Genetics Herpesvirus 4, Human Lymphocyte Depletion Open Reading Frames T-Lymphocytes, Cytotoxic Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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