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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Carlis, John V. Lifson, Jeffrey D. Haase, Ashley T. Waterman, Diane Kohler, Heinz Pambuccian, Stefan Voss, James E. Derdeyn, Cynthia A. Wietgrefe, Stephen Johnson, R. Paul Zeng, Ming Reeves, R. Keith Reilly, Cavan S. Piatak, Michael Li, Qingsheng Müller, Sybille Skinner, Pamela J. Burton, Dennis R. Shang, Liang Southern, Peter J. Evans, David T. Smith, Anthony J. Zupancic, Mary L. Duan, Lijie Alpert, Michael D. Masek-Hammerman, Katherine Robinson, James |
| Description | Author Affiliation: Li Q ( Department of Microbiology, Medical School, University of Minnesota, Minneapolis, MN 55455); Zeng M ( Department of Microbiology, Medical School, University of Minnesota, Minneapolis, MN 55455); Duan L ( Department of Microbiology, Medical School, University of Minnesota, Minneapolis, MN 55455); Voss JE ( Department of Immunology and Microbial Science, International AIDS Vaccine Initiative Neutralizing Antibody Center, and Center for HIV/AIDS Vaccine Immunology and Immunogen Design, The Scripps Research Institute, La Jolla, CA 92037); Smith AJ ( Department of Microbiology, Medical School, University of Minnesota, Minneapolis, MN 55455); Pambuccian S ( Department of Laboratory Medicine and Pathology, Medical School, University of Minnesota, Minneapolis, MN 55455); Shang L ( Department of Microbiology, Medical School, University of Minnesota, Minneapolis, MN 55455); Wietgrefe S ( Department of Microbiology, Medical School, University of Minnesota, Minneapolis, MN 55455); Southern PJ ( Department of Microbiology, Medical School, University of Minnesota, Minneapolis, MN 55455); Reilly CS ( Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN 55455); Skinner PJ ( Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108); Zupancic ML ( Department of Microbiology, Medical School, University of Minnesota, Minneapolis, MN 55455); Carlis JV ( Department of Computer Science and Engineering, College of Science and Engineering, University of Minnesota, Minneapolis, MN 55455); Piatak M ( AIDS and Cancer Virus Program, Science Applications International Corporation-Frederick, Inc., National Cancer Institute, Frederick, MD 21702); Waterman D ( ZeptoMetrix Corporation, Buffalo, NY 14202); Reeves RK ( New England Primate Research Center, Harvard Medical School, Southborough, MA 01772); Masek-Hammerman K ( New England Primate Research Center, Harvard Medical School, Southborough, MA 01772); Derdeyn CA ( Department of Pathology and Laboratory Medicine and Emory Vaccine Center, Emory University, Yerkes, Atlanta, GA 30329); Alpert MD ( New England Primate Research Center, Harvard Medical School, Southborough, MA 01772); Evans DT ( New England Primate Research Center, Harvard Medical School, Southborough, MA 01772); Kohler H ( Department of Microbiology and Immunology and Molecular Genetics, University of Kentucky, Lexington, KY 40536); Müller S ( ImmPheron Inc., Lexington, KY 40509); Robinson J ( Department of Pediatrics, Center for Infectious Diseases, Tulane University, New Orleans, LA 70112.); Lifson JD ( AIDS and Cancer Virus Program, Science Applications International Corporation-Frederick, Inc., National Cancer Institute, Frederick, MD 21702); Burton DR ( Department of Immunology and Microbial Science, International AIDS Vaccine Initiative Neutralizing Antibody Center, and Center for HIV/AIDS Vaccine Immunology and Immunogen Design, The Scripps Research Institute, La Jolla, CA 92037); Johnson RP ( Ragon Institute of MGH, MIT, and Harvard, Charlestown, MA 02129); Haase AT ( Department of Microbiology, Medical School, University of Minnesota, Minneapolis, MN 55455) |
| Abstract | We sought design principles for a vaccine to prevent HIV transmission to women by identifying correlates of protection conferred by a highly effective live attenuated SIV vaccine in the rhesus macaque animal model. We show that SIVmac239Δnef vaccination recruits plasma cells and induces ectopic lymphoid follicle formation beneath the mucosal epithelium in the rhesus macaque female reproductive tract. The plasma cells and ectopic follicles produce IgG Abs reactive with viral envelope glycoprotein gp41 trimers, and these Abs are concentrated on the path of virus entry by the neonatal FcR in cervical reserve epithelium and in vaginal epithelium. This local Ab production and delivery system correlated spatially and temporally with the maturation of local protection against high-dose pathogenic SIV vaginal challenge. Thus, designing vaccines to elicit production and concentration of Abs at mucosal frontlines could aid in the development of an effective vaccine to protect women against HIV-1. |
| ISSN | 00221767 |
| e-ISSN | 15506606 |
| DOI | 10.4049/jimmunol.1400820 |
| Journal | The Journal of Immunology |
| Issue Number | 6 |
| Volume Number | 193 |
| Language | English |
| Publisher | The American Association of Immunologists |
| Publisher Date | 2014-09-15 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Cervix Uteri Immunology Saids Vaccines Simian Acquired Immunodeficiency Syndrome Prevention & Control Simian Immunodeficiency Virus Vagina Animals Antibodies, Neutralizing Antibodies, Viral Antibody Formation Virology Hiv Envelope Protein Gp41 Hiv Infections Hiv-1 Immunoglobulin G Biosynthesis Macaca Mulatta Mucous Membrane Administration & Dosage Vaccination Vaccines, Attenuated Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Immunology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
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