NDLI: Cutting Edge: Enhanced Clonal Burst Size Corrects an Otherwise Defective Memory Response by CD8+ Recent Thymic Emigrants.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Deets, Katherine A. Berkley, Amy M. Bergsbaken, Tessa Fink, Pamela J.
Description	Author Affiliation: Deets KA ( Department of Immunology, University of Washington, Seattle, WA 98109.); Berkley AM ( Department of Immunology, University of Washington, Seattle, WA 98109.); Bergsbaken T ( Department of Immunology, University of Washington, Seattle, WA 98109.); Fink PJ ( Department of Immunology, University of Washington, Seattle, WA 98109 pfink@uw.edu.)
Abstract	The youngest peripheral T cells (recent thymic emigrants [RTEs]) are functionally distinct from naive T cells that have completed postthymic maturation. We assessed the RTE memory response and found that RTEs produced less granzyme B than their mature counterparts during infection but proliferated more and, therefore, generated equivalent target killing in vivo. Postinfection, RTE numbers contracted less dramatically than those of mature T cells, but RTEs were delayed in their transition to central memory, displaying impaired expression of CD62L, IL-2, Eomesodermin, and CXCR4, which resulted in impaired bone marrow localization. RTE-derived and mature memory cells expanded equivalently during rechallenge, indicating that the robust proliferative capacity of RTEs was maintained independently of central memory phenotype. Thus, the diminished effector function and delayed central memory differentiation of RTE-derived memory cells are counterbalanced by their increased proliferative capacity, driving the efficacy of the RTE response to that of mature T cells.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	6
Volume Number	196
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2016-03-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cd8-positive T-lymphocytes Cytology Immunology Immunologic Memory Lymphocyte Activation Adoptive Transfer Animals Cell Differentiation Cell Separation Flow Cytometry Mice Mice, Transgenic Thymus Gland Research Support, N.i.h., Extramural Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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