NDLI: La(III) complex involving the O,N-donor environment of quinazoline-4(3H)-one Schiff's base and their antimicrobial attributes against methicillin-resistant Staphylococcus aureus (MRSA).

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Mane, Sunilkumar B. Manikprabhu, Deene Siddappa, K.
Spatial Coverage	India
Description	Author Affiliation: Siddappa K ( Department of Post-Graduate Studies and Research in Chemistry, Gulbarga University, Gulbarga 585 106, Karnataka, India. Electronic address: siddappa_65@rediffmail.com.); Mane SB ( Department of Post-Graduate Studies and Research in Chemistry, Gulbarga University, Gulbarga 585 106, Karnataka, India.); Manikprabhu D ( Department of Microbiology, Gulbarga University, Gulbarga 585 106, Karnataka, India.)
Abstract	The incidence of methicillin-resistant Staphylococcus aureus increased during the past few decades, so there is an urgent need of new antimicrobial agents if public health is concerned. Though the Schiff's bases and La(III) complex have enormous biological activity, but less attention was given in their synthesis. In the present investigation, we synthesized a new (E)-3-((2-hydroxynaphthalen-1-yl) methyleneamino)-2-methylquinazoline-4(3H)-one HNMAMQ Schiff's base by the condensation of 3-(2-aminophenyl) quinazolin-2-methyl-4(3H)-one and 2-hydroxy-1-naphthaldehyde. The Schiff's base HNMAMQ and its La(III) complex were characterized by elemental analyses, IR, NMR, mass spectra, and thermal studies. The newly synthesized Schiff's base HNMAMQ and its La(III) complex were evaluated for their antimicrobial activity against methicillin-resistant Staphylococcus aureus isolated from the Gulbarga region in India. The Schiff's base HNMAMQ and its La(III) complex showed good antimicrobial activity and thus represents a potential new drug of choice.
ISSN	13861425
Volume Number	130
e-ISSN	18733557
Journal	Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
Language	English
Publisher	Elsevier
Publisher Date	2014-09-15
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Anti-bacterial Agents Chemistry Lanthanum Methicillin-resistant Staphylococcus Aureus Nitrogen Oxygen Quinazolinones Schiff Bases Chemistry, Pharmaceutical Drug Design Hot Temperature India Magnetic Resonance Spectroscopy Mass Spectrometry Microbial Sensitivity Tests Spectrophotometry, Infrared Journal Article Research Support, Non-u.s. Gov't Discipline Spectroscopy
Content Type	Text
Resource Type	Article
Subject	Spectroscopy Atomic and Molecular Physics, and Optics Analytical Chemistry Instrumentation

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