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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Bilge, Duygu Severcan, Feride Sahin, Ipek Kazanci, Nadide |
| Description | Country affiliation: Turkey Author Affiliation: Bilge D ( Department of Physics, Faculty of Science, Ege University, 35100 Izmir, Turkey.); Sahin I ( Department of Physics, Faculty of Science, Ege University, 35100 Izmir, Turkey.); Kazanci N ( Department of Physics, Faculty of Science, Ege University, 35100 Izmir, Turkey. Electronic address: nadide.kazanci@ege.edu.tr.); Severcan F ( Department of Biological Sciences, Middle East Technical University, 06531 Ankara, Turkey.) |
| Abstract | Interactions of a non-steroidal antiestrogen drug, tamoxifen (TAM), with distearoyl-sn-glycero-3-phosphatidylcholine (DSPC) multilamellar liposomes (MLVs) were investigated as a function of drug concentration (1-15 mol%) by using two noninvasive techniques, namely Fourier transform infrared (FTIR) spectroscopy and differential scanning calorimetry (DSC). FTIR spectroscopy results show that increasing TAM concentrations (except 1 mol%) increased the wavenumbers of the CH2 stretching modes, implying an disordering effect for DSPC MLVs both in the gel and liquid crystalline phases. The bandwidth values of the CH2 stretchings except for 1 mol% increased when TAM concentrations increased for DSPC liposomes, indicating an increase in the dynamics of liposomes. The CO stretching and PO2- antisymmetric double bond stretching bands were analyzed to study interactions of TAM with head groups of lipids. As the concentrations of TAM increased, dehydration occurred around these functional groups in the polar part of the lipids. The DSC studies on thermal properties of DSPC lipids indicate that TAM eliminated the pre transition, shifted the main phase transition to lower temperatures and broadened the phase transition curve of the liposomes. |
| ISSN | 13861425 |
| Volume Number | 130 |
| e-ISSN | 18733557 |
| Journal | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2014-09-15 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Calorimetry, Differential Scanning Phosphatidylcholines Chemistry Spectroscopy, Fourier Transform Infrared Tamoxifen Cell Line, Tumor Drug Effects Humans Lipids Liposomes Membranes, Artificial Neoplasms Pathology Temperature Journal Article Discipline Spectroscopy |
| Content Type | Text |
| Resource Type | Article |
| Subject | Spectroscopy Atomic and Molecular Physics, and Optics Analytical Chemistry Instrumentation |
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