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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ghourchian, H. Goodarzi, M. Farhadi, M. Shourian, M. Ahmad, F. Moosavi-Movahedi, A. A. Sheibani, N. Habibi-Rezaei, M. Saboury, A. A. |
| Description | Country affiliation: Iran Author Affiliation: Goodarzi M ( Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran.); Moosavi-Movahedi AA ( Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran); Habibi-Rezaei M ( School of Biology, University of Tehran, Tehran, Iran); Shourian M ( Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran.); Ghourchian H ( Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran.); Ahmad F ( Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi 110025, India.); Farhadi M ( ENT-HNS Research Center, IUMS, Tehran, Iran.); Saboury AA ( Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran); Sheibani N ( Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.) |
| Abstract | Protein glycation is a cascade of nonenzymatic reactions between reducing sugars and amino groups of proteins. It is referred to as fructation when the reducing monosaccharide is fructose. Some potential mechanisms have been suggested for the generation of reactive oxygen species (ROS) by protein glycation reactions in the presence of glucose. In this state, glucose autoxidation, ketoamine, and oxidative advance glycation end products (AGEs) formation are considered as major sources of ROS and perhaps heme degradation during hemoglobin glycation. However, whether fructose mediated glycation produces ROS and heme degradation is unknown. Here we report that ROS (H2O2) production occurred during hemoglobin fructation in vitro using chemiluminescence methods. The enhanced heme exposure and degradation were determined using UV-Vis and fluorescence spectrophotometry. Following accumulation of ROS, heme degradation products were accumulated reaching a plateau along with the detected ROS. Thus, fructose may make a significant contribution to the production of ROS, glycation of proteins, and heme degradation during diabetes. |
| ISSN | 13861425 |
| Volume Number | 130 |
| e-ISSN | 18733557 |
| Journal | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2014-09-15 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Fructose Chemistry Heme Hemoglobins Reactive Oxygen Species Spectrometry, Fluorescence Spectrophotometry, Ultraviolet Erythrocytes Metabolism Glucose Glycosylation End Products, Advanced Humans Hydrogen Peroxide Hyperglycemia Luminescence Proteins Solvents Journal Article Research Support, Non-u.s. Gov't Discipline Spectroscopy |
| Content Type | Text |
| Resource Type | Article |
| Subject | Spectroscopy Atomic and Molecular Physics, and Optics Analytical Chemistry Instrumentation |
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