NDLI: Role of REG I in gastric carcinogenesis: Gastrin-associated proliferative and anti-apoptotic activities.

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Role of REG I in gastric carcinogenesis: Gastrin-associated proliferative and anti-apoptotic activities.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wang, Liangjing Zhou, Qunyan Gan, Lihong Zhou, Tianhua Lu, Xiaofeng Chen, Shujie Si, Jianmin
Description	Author Affiliation: Zhou Q ( Laboratory of Digestive Disease, Clinical Institution of Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou 310016, P.R. China.)
Abstract	Gastric carcinogenesis is a multiple-stage process. It is believed that a premalignant lesion often precedes or accompanies gastric cancer, although the underlying mechanisms have not been fully elucidated. Here, we revealed that REG I was frequently overexpressed not only in gastric cancer tissues, but also in the intestinal metaplastic and atypical dysplasia gland, which are considered precancerous lesions, in 102 patients. To investigate the role of REG I in gastric cancer, we employed siRNA-mediated silencing techniques and found that the downregulation of REG I significantly inhibited gastric cancer cell proliferation, whereas overexpression of REG I promoted proliferation. In addition, REG I appeared to have an anti-apoptotic effect in gastric cancer cells, which was associated with the Bad/Bcl-xL/caspase-3 pathway. Furthermore, gastrin was found to activate REG I expression and nuclear translocation of ß-catenin in gastric cancer cells. Thus, these data suggest that REG I , a potential downstream of gastrin, may be involved in gastric carcinogenesis.
ISSN	17912997
e-ISSN	17913004
Journal	Molecular Medicine Reports
Issue Number	6
Volume Number	3
Language	English
Publisher	Spandidos Publications
Publisher Date	2010-11-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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