NDLI: Involvement of Foxp3-expressing $CD4^{+}$ $CD25^{+}$regulatory T cells in the development of tolerance induced by transforming growth $factor-β

Please wait, while we are loading the content...

Involvement of Foxp3-expressing $CD4^{+}$ $CD25^{+}$regulatory T cells in the development of tolerance induced by transforming growth $factor-β_{2}$-treated antigen-presenting cells

Content Provider	Scilit
Author	Zhang, Haining Yang, Peizeng Zhou, Hongyan Meng, Qianli Huang, Xiangkun
Copyright Year	2008
Description	Journal: Immunology A growing body of evidence has shown that professional antigen-presenting cells (APC) treated with transforming growth factor-beta (TGF-beta) can induce a systemic antigen (Ag)-specific tolerance, similar to anterior chamber-associated immune deviation (ACAID). However, the exact mechanism for immune tolerance induced by TGF-beta-treated APC has not been elucidated. In this study, we showed that intravenous injection of ovalbumin (OVA)-pulsed APC treated with TGF-beta(2) induced a peripheral tolerance as evidenced by an impaired delayed-type hypersensitivity (DTH) response. CD4(+) T cells from mice receiving an intravenous injection of TGF-beta(2)-treated APC pulsed with OVA could adoptively transfer a specific tolerance to naïve mice. An increased frequency of FoxP3-expressing CD4(+) CD25(+) T cells was observed in mice with tolerance. CD4(+ )CD25(+) T cells from TGF-beta(2)-treated APC-injected mice produced a large amount of TGF-beta(1) and exhibited an in vitro antigen-specific suppressive activity. CD4(+) CD25(+) T cells from TGF-beta(2)-treated APC-injected mice were able to inhibit the antigen-specific DTH response significantly when adoptively transferred to naïve mice. These results indicate that FoxP3-expressing CD4(+) CD25(+) T cells might be actively involved in the development of tolerance induced by TGF-beta(2)-treated APC.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2440824/pdf http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2567.2007.02769.x/pdf
Ending Page	314
Page Count	11
Starting Page	304
e-ISSN	13652567
DOI	10.1111/j.1365-2567.2007.02769.x
Journal	Immunology
Issue Number	3
Volume Number	124
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2008-07-01
Access Restriction	Open
Subject Keyword	Journal: Immunology Biochemistry and Molecular Biology Cd4+ Cd25+ T Cells Immune Tolerance Tgf‐β2‐treated Apc
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Involvement of Foxp3-expressing CD4+ CD25+ regulatory T cells in the development of tolerance induced by transforming growth factor-β2-treated antigen-presenting cells

Thrombospondin-1-dependent immune regulation by transforming growth $factor-β_{2}$-exposed antigen-presenting cells

Maizels, “Expansion and activation of CD4 + CD25 + regulatory T cells in Heligmosomoides polygyrus infection

Distinct regulatory roles of transforming growth factor-β and interleukin-4 in the development and maintenance of natural and induced $CD4^{+}$ $CD25^{+}$ $Foxp3^{+}$regulatory T cells

Conversion of peripheral cd4 - cd25 - naive t cells to cd4 - cd25 - regulatory t cells by tgf- - induction of transcription factor foxp3.

Human Umbilical Vein Endothelial Cells foster conversion of CD4+CD25-Foxp3- T cells into CD4+Foxp3+ Regulatory T Cells via Transforming Growth Factor-β.

CD4+CD25+Foxp3+ T Cells and CD4+CD25−Foxp3+ T Cells in Aged Mice

Cutting Edge: Foxp3+CD4+CD25+ Regulatory T Cells Induced by IL-2 and TGF-β Are Resistant to Th17 Conversion by IL-6

A paragon of self-tolerance: CD25+CD4+regulatory T cells and the control of immune responses

Involvement of Foxp3-expressing $CD4^{+}$ $CD25^{+}$regulatory T cells in the development of tolerance induced by transforming growth $factor-β_{2}$-treated antigen-presenting cells

Similar Documents

Involvement of Foxp3-expressing CD4+ CD25+ regulatory T cells in the development of tolerance induced by transforming growth factor-β2-treated antigen-presenting cells

Thrombospondin-1-dependent immune regulation by transforming growth $factor-β_{2}$-exposed antigen-presenting cells

Maizels, “Expansion and activation of CD4 + CD25 + regulatory T cells in Heligmosomoides polygyrus infection

Distinct regulatory roles of transforming growth factor-β and interleukin-4 in the development and maintenance of natural and induced $CD4^{+}$ $CD25^{+}$ $Foxp3^{+}$regulatory T cells

Conversion of peripheral cd4 - cd25 - naive t cells to cd4 - cd25 - regulatory t cells by tgf- - induction of transcription factor foxp3.

Human Umbilical Vein Endothelial Cells foster conversion of CD4+CD25-Foxp3- T cells into CD4+Foxp3+ Regulatory T Cells via Transforming Growth Factor-β.

CD4+CD25+Foxp3+ T Cells and CD4+CD25−Foxp3+ T Cells in Aged Mice

Cutting Edge: Foxp3+CD4+CD25+ Regulatory T Cells Induced by IL-2 and TGF-β Are Resistant to Th17 Conversion by IL-6

A paragon of self-tolerance: CD25+CD4+regulatory T cells and the control of immune responses

Involvement of Foxp3-expressing $CD4^{+}$ $CD25^{+}$regulatory T cells in the development of tolerance induced by transforming growth $factor-β_{2}$-treated antigen-presenting cells