NDLI: CYP1A1m2 polymorphisms regulate estrogen and interleukin-6 in lung cancer.

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CYP1A1m2 polymorphisms regulate estrogen and interleukin-6 in lung cancer.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Anil Kumar, V. Sreelekha, T. T. Rajesh, M. Madhavan, J. Balaram, P.
Description	Country affiliation: India Author Affiliation: Sreelekha TT ( Division of Cancer Research, Regional Cancer Centre, Trivandrum, India.)
Abstract	Lung cancer, the most common cause of cancer-related death in men and women, is responsible for 1.3 million deaths worldwide annually. Women are diagnosed to a greater extent than men with adenocarcinoma and small cell carcinoma, both of which are secretory-type tumors. Never smokers diagnosed with lung cancer are also predominantly female, demonstrating the association of genetic factors with lung carcinogenesis. Several epidemiologic studies have associates certain CYP1A1 genotypes, alone or in combination, with an increased risk of estrogen-related cancer. The aim of this study was to investigate the impact of the CYP and GST polymorphisms along with estrogen and interleukin-6 (IL-6) levels on the risk of lung cancer. Eighty-six lung cancer patients and 60 controls were included in the study. A significantly higher frequency of polymorphisms in the genes was observed in lung cancer patients compared to controls. Mean estradiol concentration was reduced and IL-6 levels were elevated in patients compared to controls. In conclusion, increased polymorphisms in metabolic genes may be the reason for the reduced estradiol and, thereby, the increased expression of IL-6 in the serum of lung cancer patients.
ISSN	17912997
e-ISSN	17913004
Journal	Molecular Medicine Reports
Issue Number	6
Volume Number	3
Language	English
Publisher	Spandidos Publications
Publisher Date	2010-11-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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