NDLI: Euphol arrests breast cancer cells at the G1 phase through the modulation of cyclin D1, p21 and p27 expression.

Please wait, while we are loading the content...

Cyclopamine increases the radiosensitivity of human pancreatic cancer cells by regulating the DNA repair signal pathway through an epidermal growth factor receptordependent pathway.

Differential hepatic stem cell proliferation and differentiation after partial hepatectomy in rats.

Vascular endothelial growth factor 634G/C polymorphism is associated with increased breast cancer risk and aggressiveness.

Lycium barbarum polysaccharides induce Toll-like receptor 2- and 4-mediated phenotypic and functional maturation of murine dendritic cells via activation of NF-κB.

Microembolic signal monitoring of TOASTclassified cerebral infarction patients.

Hydrogen sulfide attenuates the inflammatory response in a mouse burn injury model.

Tetramethylpyrazine inhibits osteosarcoma cell proliferation via downregulation of NF-κB in vitro and in vivo.

RACK1 promotes prostate cancer cell proliferation, invasion and metastasis.

Effects of instrument settings on radiofrequency ultrasound local estimator images: a preliminary study in a gallbladder model.

Ultrastructural pathological changes in the cochlear cells of connexin 26 conditional knockout mice.

MicroRNA-10b promotes the migration of mouse bone marrow-derived mesenchymal stem cells and downregulates the expression of E-cadherin.

A novel heteroplasmic mitochondrial DNA mutation, A8890G, in a patient with juvenileonset metabolic syndrome: a case report.

SNPs and interaction analyses of IRF6, MSX1 and PAX9 genes in patients with nonsyndromic cleft lip with or without palate.

Association of forkhead box J3 (FOXJ3) polymorphisms with rheumatoid arthritis.

Dual-delivery of vancomycin and icariin from an injectable calcium phosphate cement-release system for controlling infection and improving bone healing.

Recombinant human histidine triad nucleotide-binding protein 1 attenuates liver fibrosis induced by carbon tetrachloride in rats.

Effect of CLC-2 on the cytoskeleton in human trabecular meshwork cells.

Forward mandibular positioning enhances the expression of Ang-1 and Ang-2 in rabbit condylar chondrocytes.

ADAM33 protein expression and the mechanics of airway smooth muscle cells are highly correlated in ovalbumin-sensitized rats.

Pravastatin slows the progression of heart failure by inhibiting the c-Jun N-terminal kinase-mediated intrinsic apoptotic signaling pathway.

Genetic analysis of a 12-year-old boy with X-linked ichthyosis in association with sclerosing glomerulonephritis.

Relevance of class 1 integrons and extended-spectrum ß-lactamases in drug-resistant Escherichia coli.

Correlation between antibodies and histology in celiac disease: incidence of celiac disease is higher than expected in the pediatric population.

Neuroprotective effect of brain-derived neurotrophic factor mediated by autophagy through the PI3K/Akt/mTOR pathway.

High concentrations of pyridoxal stimulate the expression of IGFBP1 in HepG2 cells through upregulation of the ERK/cJun pathway.

The effect of alendronate on the expression of important cell factors in osteoclasts.

Effects of sterigmatocystin on esophageal epithelium and experimental reflux esophagitis in rats.

Determination of the effects of lactoferrin in a preclinical mouse model of experimental colitis.

Effects of electroacupuncture on spinal -amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor in rats injected with complete Freund's adjuvant.

Endoscopic characteristics and causes of misdiagnosis of intestinal schistosomiasis.

Euphol arrests breast cancer cells at the G1 phase through the modulation of cyclin D1, p21 and p27 expression.

Bladder cancer cell-derived exosomes inhibit tumor cell apoptosis and induce cell proliferation in vitro.

Anti-inflammatory effects of kudingcha methanol extract (Ilex kudingcha C.J. Tseng) in dextran sulfate sodium-induced ulcerative colitis.

Radiotherapyinduced Gadd45a impairs lacrimal gland epithelial cell migration and proliferation.

Chondrogenic differentiation of human umbilical cord bloodderived mesenchymal stem cells by coculture with rabbit chondrocytes.

Effects of stromal cell derived factor-1 and CXCR4 on the promotion of neovascularization by hyperbaric oxygen treatment in skin flaps.

miR-218 is downregulated and directly targets SH3GL1 in childhood medulloblastoma.

Alantolactone induces apoptosis in RKO cells through the generation of reactive oxygen species and the mitochondrial pathway.

Inhibitory effect of TGF-ß1 on NO production in peritoneal macrophages from collagen-induced arthritis rats involving the LPS-TLR4 pathway.

Apolipoprotein A5 gene variants and the risk of coronary heart disease: a casecontrol study and metaanalysis.

hClock gene expression in human colorectal carcinoma.

3-nitrotyrosine, a biomarker for cardiomyocyte apoptosis induced by diabetic cardiomyopathy in a rat model.

Predominant role of vasoconstrictors over dilatators derived from arachidonic acid in hypoxic pulmonary vasoconstriction.

Inhibitory effect of dsRNA TLR3 agonist in a rat hepatocellular carcinoma model.

Effect of anti-osteoporotic agents on the prevention of bone loss in unloaded bone.

Prevalence of infarct and villous clumps, and the expression of -smooth muscle actin in the placental basal plate in severe preeclampsia.

Chlorogenic acid induced apoptosis and inhibition of proliferation in human acute promyelocytic leukemia HL60 cells.

Monophosphoryl lipid A induces bone marrow precursor cells to differentiate into myeloid-derived suppressor cells.

Regulation of plasminogen activator activity and expression by cyclic mechanical stress in rat mandibular condylar chondrocytes.

CpG oligodeoxynucleotide induces bone marrow precursor cells into myeloid-derived suppressor cells.

Year: 2013 Volume: 8 Issue: 3

Year: 2013 Volume: 8 Issue: 2

Year: 2013 Volume: 8 Issue: 1

Euphol arrests breast cancer cells at the G1 phase through the modulation of cyclin D1, p21 and p27 expression.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Xu, Yanxin Yang, Dandan Feng, Bo Guo, Xudong Wang, Lin Kang, Jiuhong Wang, Guiying
Description	Author Affiliation: Wang L ( Department of Endocrinology, East Hospital, Tongji University School of Medicine, Yangpu, Shanghai 200092, P.R. China.)
Abstract	Euphorbia tirucalli is a longestablished treatment for a wide variety of cancers. However, the mechanism of its anticancer effect is yet to be elucidated. In the present study, we examined the anticancer effect of euphol, a tetracyclic triterpene alcohol isolated from the sap of Euphorbia tirucalli, in T47D human breast cancer cells. Following the treatment of cells with different doses of euphol for 24, 48 and 72 h, the cell proliferation, cell cycle, and mRNA and protein levels of cell cycle regulatory molecules were analyzed, respectively. Treatment of the cells with euphol resulted in decreased cell viability, which was accompanied by an accumulation of cells in the G1 phase. Further studies demonstrated that euphol treatment downregulated cyclin D1 expression and the hypophosphorylation of Rb. Furthermore, this effect was correlated with the downregulation of cyclindependent kinase 2 (CDK2) expression and the upregulation of the CDK inhibitors p21 and p27. Reduced expression levels of cyclin A and B1 were also observed, corresponding to the decreased distribution of cells in the S and G2/M phases, respectively. These findings indicated that euphol is an active agent in Euphorbia tirucalli that exerts anticancer activity by arresting the cell cycle of cancer cells.
ISSN	17912997
e-ISSN	17913004
Journal	Molecular Medicine Reports
Issue Number	4
Volume Number	8
Language	English
Publisher	Spandidos Publications
Publisher Date	2013-10-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Antineoplastic Agents, Phytogenic Pharmacology Cyclin D1 Metabolism Cyclin-dependent Kinase Inhibitor P21 Cyclin-dependent Kinase Inhibitor P27 G1 Phase Cell Cycle Checkpoints Drug Effects Lanosterol Analogs & Derivatives Breast Neoplasms Cell Line, Tumor Cell Proliferation Genetics Drug Screening Assays, Antitumor Gene Expression Gene Expression Regulation, Neoplastic Retinoblastoma Transcription, Genetic Research Support, Non-u.s. Gov't Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Cell cycle regulation by bevacizumab in ARPE-19 human retinal pigment epithelial cells.

GLP-1 ameliorates the proliferation activity of INS-1 cells inhibited by intermittent high glucose concentrations through the regulation of cyclins.

BDE-47 and BDE-209 inhibit proliferation of Neuro-2a cells via inducing G1-phase arrest.

Triptolide inhibits colon-rectal cancer cells proliferation by induction of G1 phase arrest through upregulation of p21.

Resveratrol inhibits proliferation in human colorectal carcinoma cells by inducing G1/Sphase cell cycle arrest and apoptosis through caspase/cyclinCDK pathways.

Induction of cell cycle arrest via the p21, p27-cyclin E,A/Cdk2 pathway in SMMC-7721 hepatoma cells by clioquinol.

High expression of microRNA127 is involved in cell cycle arrest in MC3 mucoepidermoid carcinoma cells.

Exogenous activation of LKB1/AMPK signaling induces G1 arrest in cells with endogenous LKB1 expression.

Nucleolar GTP-binding Protein-1 (NGP-1) Promotes G1 to S Phase Transition by Activating Cyclin-dependent Kinase Inhibitor p21 Cip1/Waf1.

Euphol arrests breast cancer cells at the G1 phase through the modulation of cyclin D1, p21 and p27 expression.

Similar Documents

Cell cycle regulation by bevacizumab in ARPE-19 human retinal pigment epithelial cells.

GLP-1 ameliorates the proliferation activity of INS-1 cells inhibited by intermittent high glucose concentrations through the regulation of cyclins.

BDE-47 and BDE-209 inhibit proliferation of Neuro-2a cells via inducing G1-phase arrest.

Triptolide inhibits colon-rectal cancer cells proliferation by induction of G1 phase arrest through upregulation of p21.

Resveratrol inhibits proliferation in human colorectal carcinoma cells by inducing G1/S­phase cell cycle arrest and apoptosis through caspase/cyclin­CDK pathways.

Induction of cell cycle arrest via the p21, p27-cyclin E,A/Cdk2 pathway in SMMC-7721 hepatoma cells by clioquinol.

High expression of microRNA­127 is involved in cell cycle arrest in MC­3 mucoepidermoid carcinoma cells.

Exogenous activation of LKB1/AMPK signaling induces G1 arrest in cells with endogenous LKB1 expression.

Nucleolar GTP-binding Protein-1 (NGP-1) Promotes G1 to S Phase Transition by Activating Cyclin-dependent Kinase Inhibitor p21 Cip1/Waf1.

Euphol arrests breast cancer cells at the G1 phase through the modulation of cyclin D1, p21 and p27 expression.

Resveratrol inhibits proliferation in human colorectal carcinoma cells by inducing G1/Sphase cell cycle arrest and apoptosis through caspase/cyclinCDK pathways.

High expression of microRNA127 is involved in cell cycle arrest in MC3 mucoepidermoid carcinoma cells.