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Hydrogen sulfide attenuates the inflammatory response in a mouse burn injury model.

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Hydrogen sulfide attenuates the inflammatory response in a mouse burn injury model.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Li, Changqing Fan, Haipeng Zeng, Jianhong Lin, Xianhe
Description	Author Affiliation: Zeng J ( College of Pharmacy, Guilin Medical University, Guilin, Guangxi 541004, P.R. China.)
Abstract	Hydrogen sulfide (H2S) is a naturally occurring gaseous transmitter, which is important in normal physiology and disease. In the present study, the involvement of H2S in the regulation of the immune response induced by burn injury was investigated in mice. Adult male C57BL/6 mice were subjected to burn injuries and treated with vehicle (0.9% sodium chloride, NaCl; 100 ml/kg body weight; subcutaneously, s.c.) or the H2S donor (sodium hydrosulfide, NaHS; 2 mg/kg body weight; s.c.). Compared with the controls, mice which received burn injuries exhibited a significant decrease in plasma H2S levels. Moreover, the levels of tumor necrosis factor (TNF) , interleukin (IL)6 and IL8 significantly increased, while IL10 levels were decreased, compared with that of the controls in the plasma of mice subjected to burn injuries. Myeloperoxidase (MPO) activity in the liver tissue of injured mice was also markedly higher compared with that of the control group. However, the administration of NaHS significantly decreased the levels of TNF , IL6 and IL8 but increased the levels of IL10 in the plasma of mice subjected to burn injuries. In addition, the MPO activity was decreased by NaHS. These results suggested that H2S regulates the inflammatory response induced by burn injury by modulating the levels of TNF , IL6, IL8 and IL10. Thus, it was proposed that the administration of the H2S donor, NaHS, may be a useful therapy against the exaggerated immune response that is associated with burn injury.
ISSN	17912997
e-ISSN	17913004
Journal	Molecular Medicine Reports
Issue Number	4
Volume Number	8
Language	English
Publisher	Spandidos Publications
Publisher Date	2013-10-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Anti-inflammatory Agents Pharmacology Burns Drug Therapy Sulfides Animals Blood Immunology Hydrogen Sulfide Inflammation Mediators Interleukin-10 Interleukin-6 Interleukin-8 Liver Enzymology Mice Mice, Inbred C57bl Peroxidase Metabolism Tumor Necrosis Factor-alpha Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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