NDLI: Monophosphoryl lipid A induces bone marrow precursor cells to differentiate into myeloid-derived suppressor cells.

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Monophosphoryl lipid A induces bone marrow precursor cells to differentiate into myeloid-derived suppressor cells.

Regulation of plasminogen activator activity and expression by cyclic mechanical stress in rat mandibular condylar chondrocytes.

CpG oligodeoxynucleotide induces bone marrow precursor cells into myeloid-derived suppressor cells.

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Monophosphoryl lipid A induces bone marrow precursor cells to differentiate into myeloid-derived suppressor cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhao, Xiuhua Chen, Maomao Huang, Yong Lei, Wanke Liu, Junxia Sun, Weimin Liang, Dong Sun, Baomu Chen, Jie
Description	Author Affiliation: Chen J ( Department of Ophthalmology, 117th Hospital of PLA, Hangzhou, Zhejiang 310013, P.R. China.)
Abstract	Myeloid-derived suppressor cells (MDSCs) and dendritic cells (DCs) are important in the immune response. In vitro, DCs are derived from myeloid precursors by stimulation with granulocyte macrophage colonystimulating factor and interleukin4. Previous studies demonstrated that lipopolysaccharide (LPS) in combination with interferonÎ³ inhibited DC development but enhanced MDSC functions. Monophosphoryl lipid A (MPL), derived from LPS, is a unique immunomodulatory Tolllike receptor 4 agonist. In the present study, MPL was used to disturb DC differentiation from myeloid precursors and it was observed that prolonged stimulation with MPL led to the accumulation of MDSCs in vitro and in vivo. In conclusion, it was demonstrated that stimulation by MPL from the beginning of cell differentiation disturbed the development of DCs and led to the accumulation of MDSCs.
ISSN	17912997
e-ISSN	17913004
Journal	Molecular Medicine Reports
Issue Number	4
Volume Number	8
Language	English
Publisher	Spandidos Publications
Publisher Date	2013-10-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Bone Marrow Cells Drug Effects Cell Differentiation Lipid A Analogs & Derivatives Myeloid Cells Physiology Animals Immunology Cell Proliferation Cells, Cultured Cytokines Metabolism Dendritic Cells Pharmacology Mice Mice, Inbred C57bl Phagocytosis Phenotype T-lymphocytes Toll-like Receptor 4 Agonists Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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