NDLI: Exogenous activation of LKB1/AMPK signaling induces G1 arrest in cells with endogenous LKB1 expression.

Please wait, while we are loading the content...

Year: 2017 Volume: 15

Year: 2016 Volume: 14

Year: 2016 Volume: 13

Year: 2015 Volume: 12

Year: 2015 Volume: 11

Year: 2014 Volume: 10

Year: 2014 Volume: 9

Year: 2014 Volume: 9 Issue: 6

Year: 2014 Volume: 9 Issue: 5

Year: 2014 Volume: 9 Issue: 4

Year: 2014 Volume: 9 Issue: 3

Gankyrin is essential for hypoxia enhanced metastatic potential in breast cancer cells.

Ginsenoside Rg1 reduces toxicity of fine particulate matter on human alveolar epithelial cells: a preliminary observation.

Dendroaspis natriuretic peptide is degraded by a metalloproteinase in the rat kidney.

Expression and DNA methylation status of microRNA-375 in patients with type 2 diabetes mellitus.

Urine tenascinC is an independent risk factor for bladder cancer patients.

Increased expression of herpesvirus entry mediator in 1,25-dihydroxyvitamin D3-treated mouse bone marrow-derived dendritic cells promotes the generation of CD4â ºCD25â ºFoxp3â º regulatory T cells.

The role of claudin-5 in blood-brain barrier (BBB) and brain metastases (review).

Production of transgenic mice expressing tumor virus A under ovarianspecific promoter 1 control using testismediated gene transfer.

Early high volume lung lavage for acute severe smoke inhalation injury in dogs.

Neuroprotective effects of orientin on hydrogen peroxideinduced apoptosis in SHSY5Y cells.

Sirt6 suppresses hepatocellular carcinoma cell growth via inhibiting the extracellular signalregulated kinase signaling pathway.

Pglycoprotein inhibition increases the transport of dauricine across the bloodbrain barrier.

Foreign body response induced by tissue expander implantation.

Generation of induced pluripotent stem cells using skin fibroblasts from patients with myocardial infarction under feeder-free conditions.

Isorhamnetin suppresses colon cancer cell growth through the PI3KAktmTOR pathway.

SUMOylation alterations are associated with multidrug resistance in hepatocellular carcinoma.

Grape seed proanthocyanidin extract protects from cisplatin-induced nephrotoxicity by inhibiting endoplasmic reticulum stress-induced apoptosis.

Effects of methanolic extract form Fuzhuan brick-tea on hydrogen peroxide-induced oxidative stress in human intestinal epithelial adenocarcinoma Caco-2 cells.

Transmembrane protein with unknown function 16A overexpression promotes glioma formation through the nuclear factor-κB signaling pathway.

ß-catenin deacetylation is essential for WNT-induced proliferation of breast cancer cells.

Vascular endothelial growth factor polymorphisms affect gene expression and tumor aggressiveness in patients with breast cancer.

Promoter methylationassociated silencing of p27kip1 gene with metastasis in esophageal squamous cell carcinoma.

Angiotensin II promotes the progression of human gastric cancer.

Α-eleostearic acid inhibits growth and induces apoptosis in breast cancer cells via HER2/HER3 signaling.

Local delivery of T-bet shRNA reduces inflammation in collagen II-induced arthritis via downregulation of IFN-Î³ and IL-17.

Store-operated Ca²â º entry mediated regulation of polarization in differentiated human neutrophil-like HL-60 cells under hypoxia.

Expression of PPAR-Î³ in adipose tissue of rats with polycystic ovary syndrome induced by DHEA.

Glycoprotein non-metastatic melanoma protein B as a predictive prognostic factor in clear-cell renal cell carcinoma following radical nephrectomy.

Survivin promotes the invasion of human colon carcinoma cells by regulating the expression of MMP7.

Cytokine IL-6 is required in Citrobacter rodentium infection-induced intestinal Th17 responses and promotes IL-22 expression in inflammatory bowel disease.

Overexpression of aquaporin1 aggravates hippocampal damage in mouse traumatic brain injury models.

MiR224 promotes colorectal cancer cells proliferation via downregulation of P21WAF1/CIP1.

Aberrant miRNA expression response to UV irradiation in human liver cancer cells.

Impact of the 4G/5G polymorphism in the plasminogen activator inhibitor-1 gene on primary nephrotic syndrome.

Effect of intervention in the diacylglycerolprotein kinase C signaling pathway on JNK1 expression and its downstream signaling in diabetic cardiomyopathy.

Effects of azathioprine and infliximab on mesenchymal stem cells derived from the bone marrow of rats in vitro.

HIF-1 silencing suppresses growth of lung adenocarcinoma A549 cells through induction of apoptosis.

Antitumor activity of CDA-â ¡, a urinary preparation, on human multiple myeloma cell lines via the mitochondrial pathway.

Sevoflurane postconditioning against cerebral ischemic neuronal injury is abolished in diet-induced obesity: role of brain mitochondrial KATP channels.

Placental leptin gene methylation and macrosomia during normal pregnancy.

In silico search for multi-target therapies for osteoarthritis based on 10 common Huoxue Huayu herbs and potential applications to other diseases.

Association of a polymorphism of BTN2A1 with dyslipidemia in community-dwelling individuals.

Facile synthesis and characterization of polyethylenimine-coated Fe3O4 superparamagnetic nanoparticles for cancer cell separation.

Synergism between upregulation of Rab7 and inhibition of autophagic degradation caused by mycoplasma facilitates intracellular mycoplasma infection.

Screening for key genes associated with atopic dermatitis with DNA microarrays.

Epigallocatechin3gallate inhibits the proliferation and migration of human ovarian carcinoma cells by modulating p38 kinase and matrix metalloproteinase2.

Dexamethasone reduces ATDC5 chondrocyte cell viability by inducing autophagy.

Exogenous activation of LKB1/AMPK signaling induces G1 arrest in cells with endogenous LKB1 expression.

Folate-polyethylene glycol conjugated carboxymethyl chitosan for tumor-targeted delivery of 5-fluorouracil.

Recombinant lentivirus targeting the pleotrophin gene reduces pleotrophin protein expression in pancreatic cancer cells and inhibits neurite outgrowth of dorsal root ganglion neurons.

Foxp3 gene expression in oral lichen planus: a clinicopathological study.

Year: 2014 Volume: 9 Issue: 2

Year: 2014 Volume: 9 Issue: 1

Year: 2013 Volume: 8

Year: 2013 Volume: 7

Year: 2012 Volume: 6

Year: 2012 Volume: 5

Year: 2011 Volume: 4

Year: 2010 Volume: 3

Year: 2008 Volume: 1

Exogenous activation of LKB1/AMPK signaling induces G1 arrest in cells with endogenous LKB1 expression.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Tao, Xiaohong Wang, Pilong Liang, Xiaoyan Gao, Qing
Description	Author Affiliation: Liang X ( Department of Gastroenterology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China.); Wang P ( Department of Gastroenterology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China.); Gao Q ( Department of Gastroenterology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China.); Tao X ( Department of Gastroenterology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China.)
Abstract	The tumor suppressor protein LKB1 is a serine/threonine kinase that plays a critical role in cell proliferation, and its inactivation has been linked to tumorigenesis in various cancer types. Current understanding of the LKB1 function is largely restricted to results from experiments on LKB1deficient cancer cells, while the regulation and activity of endogenous LKB1 has been rarely investigated. In a previous study, we showed that LKB1 knockdown in two healthy cell lines accelerates cell cycle progression through the G1/S checkpoint by inhibition of the p53 and p16 pathways. In the present study, we examined the effects of overexpression of LKB1 on two healthy and one cancer cell line. Administration of exogenous LKB1 activated LKB1/AMPK signaling and arrested the cell cycle at the G1 phase in an LKB1-dependent manner. G1 arrest induced by LKB1 was accompanied by the downregulation of cyclin D1 and cyclin D3, and the upregulation of p53, p21 and p16, while no differences were detected for CDK4, CDK6, cyclin E, p15 and p27. These results indicated that exogenous activation of LKB1/AMPK signaling inhibits the G1/S cell cycle transition, even in cells with an endogenous expression of LKB1. Findings of the present study extend earlier observations on LKB1inactivated neoplastic cells and provide novel insights into the growth-inhibitory effects of LKB1.
ISSN	17912997
e-ISSN	17913004
Journal	Molecular Medicine Reports
Issue Number	3
Volume Number	9
Language	English
Publisher	Spandidos Publications
Publisher Date	2014-03-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Amp-activated Protein Kinases Metabolism G1 Phase Cell Cycle Checkpoints Physiology Gene Expression Regulation, Enzymologic Protein-serine-threonine Kinases Genetics Signal Transduction Cyclin D1 Cyclin D3 Cyclin-dependent Kinase Inhibitor P16 Cyclin-dependent Kinase Inhibitor P27 Down-regulation Genetic Vectors Hek293 Cells Hep G2 Cells Human Umbilical Vein Endothelial Cells Phosphorylation Retinoblastoma Protein Tumor Suppressor Protein P53 Up-regulation Research Support, Non-u.s. Gov't Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in