NDLI: Regional variation in expression of pro-inflammatory mediators in the intestine following a combined insult of alcohol and burn injury.

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The reinforcing properties of ethanol are quantitatively enhanced in adulthood by peri-adolescent ethanol, but not saccharin, consumption in female alcohol-preferring (P) rats.

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Regional variation in expression of pro-inflammatory mediators in the intestine following a combined insult of alcohol and burn injury.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Morris, Niya L. Li, Xiaoling Earley, Zachary M. Choudhry, Mashkoor A.
Description	Country affiliation: United States Author Affiliation: Morris NL ( Alcohol Research Program, Burn and Shock Trauma Research Institute, Department of Surgery, Loyola University Chicago Health Sciences Division, Maywood, IL 60153, USA); Li X ( Alcohol Research Program, Burn and Shock Trauma Research Institute, Department of Surgery, Loyola University Chicago Health Sciences Division, Maywood, IL 60153, USA.); Earley ZM ( Alcohol Research Program, Burn and Shock Trauma Research Institute, Department of Surgery, Loyola University Chicago Health Sciences Division, Maywood, IL 60153, USA); Choudhry MA ( Alcohol Research Program, Burn and Shock Trauma Research Institute, Department of Surgery, Loyola University Chicago Health Sciences Division, Maywood, IL 60153, USA)
Abstract	The intestine is segmented into functionally discrete compartments (duodenum, jejunum, ileum, and colon). The present study examined whether alcohol combined with burn injury differently influences cytokine levels in different parts of the intestine. Male mice were gavaged with alcohol (â¼2.9 g/kg) 4 h prior to receiving a â¼12.5% total body surface area full thickness burn. Mice were sacrificed 1, 3, and 7 days after injury. The intestine segments (duodenum, jejunum, ileum, and colon) were harvested, homogenized, and analyzed for inflammatory mediators (IL-6, IL-18, and KC) using their respective ELISAs. KC levels were significantly increased in the jejunum, ileum, and colon following alcohol and burn injury as compared to shams. The increase in KC was â¼28-fold higher in the colon as compared to the levels observed in duodenum following alcohol and burn injury. Both IL-6 and IL-18 levels were significantly elevated in both the ileum and colon following the combined insult. There was a â¼7-fold increase in IL-6 levels in the colon as compared with the duodenum after the combined insult. Levels of IL-18 were increased by â¼1.5-fold in the colon as compared to the ileum following alcohol and burn injury. The data suggest that pro-inflammatory mediators are differentially expressed in the intestine following alcohol and burn injury.
File Format	HTM / HTML
ISSN	07418329
e-ISSN	18736823
DOI	10.1016/j.alcohol.2015.02.007
Journal	Alcohol
Issue Number	5
Volume Number	49
Language	English
Publisher	Elsevier
Publisher Date	2015-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Substance-Related Disorders Alcoholic Intoxication Metabolism Burns Inflammation Mediators Interleukin-18 Intestines Complications Animals Chemokines Interleukin-6 Mice Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Neurology Medicine Behavioral Neuroscience Health (social science) Biochemistry Toxicology

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