NDLI: Effects of human ß-defensin-3 on biofilm formationregulating genes dltB and icaA in Staphylococcus aureus.

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Effects of human ß-defensin-3 on biofilm formationregulating genes dltB and icaA in Staphylococcus aureus.

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Effects of human ß-defensin-3 on biofilm formationregulating genes dltB and icaA in Staphylococcus aureus.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Huang, Xian-Kai Huang, Qiang Fei, Jun Yu, Hong-Jun Gou, Yuan-Bin
Description	Author Affiliation: Huang Q ( Trauma Center of Daping Hospital, Third Military Medical University, Chongqing 404100, P.R. China.); Fei J ( Trauma Center of Daping Hospital, Third Military Medical University, Chongqing 404100, P.R. China.); Yu HJ ( Rehabilitation Department, Southwest Hospital, Third Military Medical University, Chongqing 404100, P.R. China.); Gou YB ( Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 404100, P.R. China.); Huang XK ( Trauma Center of Daping Hospital, Third Military Medical University, Chongqing 404100, P.R. China.)
Abstract	An understanding of the regulatory mechanisms that drive Staphylococcus aureus biofilm formation may lead to the development of an effective strategy to control the increasing number of refractory clinical infections it causes. The present study examined the effects of the antimicrobial agent human ßdefensin 3 (hBD3) and the antibiotics vancomycin and clindamycin on the expression of the S. aureus biofilm formationregulating genes, icaA and dltB, during bacterial adhesion and biofilm formation. Transcription (mRNA) levels of dlt and ica genes were measured using quantitative polymerase chain reaction, and slimes of S. aureus biofilm were examined with confocal scanning laser microscopy during S. aureus adhesion and biofilm formation. Although hBD3, vancomycin and clindamycin led to significantly attenuated biofilm formation, their treatmentassociated effects on the mRNA expression of dlt and ica were not identical. Vancomycin and clindamycin induced sustained expression of the dlt and ica genes, which may be harnessed to induce biofilm formation. However, hBD3 did not have a significant affect on the transcription level of dltB during either bacterial adhesion or biofilm formation. Therefore, the mechanism of hBD3 that regulated the suppression of biofilm formation appears to differ from the mechanisms of vancomycin and clindamycin.
ISSN	17912997
e-ISSN	17913004
Journal	Molecular Medicine Reports
Issue Number	2
Volume Number	10
Language	English
Publisher	Spandidos Publications
Publisher Date	2014-08-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Bacterial Proteins Genetics Biofilms Drug Effects Membrane Transport Proteins Staphylococcus Aureus Physiology Beta-defensins Pharmacology Anti-bacterial Agents Metabolism Clindamycin Transcription, Genetic Vancomycin Research Support, Non-u.s. Gov't Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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