NDLI: 1,8-dihydroxy-3-acetyl-6-methyl-9,10 anthraquinone exhibits a potent radiosensitizing effect with induced oncosis in human nasopharyngeal carcinoma cells.

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1,8-dihydroxy-3-acetyl-6-methyl-9,10 anthraquinone exhibits a potent radiosensitizing effect with induced oncosis in human nasopharyngeal carcinoma cells.

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1,8-dihydroxy-3-acetyl-6-methyl-9,10 anthraquinone exhibits a potent radiosensitizing effect with induced oncosis in human nasopharyngeal carcinoma cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Li, Danrong Liang, Yan Hou, Huaxin Mo, Yuanyuan Chen, Donglian Jiang, Wei
Description	Author Affiliation: Hou H ( Department of Pharmaceutical Analysis, College of Pharmacy, Guangxi Medical University, Nanning, Guangxi 530021, P.R. China.); Li D ( Department of Cellular Biology, The Medical Scientific Research Centre of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China.); Jiang W ( Department of Pharmaceutical Analysis, College of Pharmacy, Guangxi Medical University, Nanning, Guangxi 530021, P.R. China.); Liang Y ( Department of Pharmaceutical Analysis, College of Pharmacy, Guangxi Medical University, Nanning, Guangxi 530021, P.R. China.); Chen D ( Department of Pharmaceutical Analysis, College of Pharmacy, Guangxi Medical University, Nanning, Guangxi 530021, P.R. China.); Mo Y ( Department of Pharmaceutical Analysis, College of Pharmacy, Guangxi Medical University, Nanning, Guangxi 530021, P.R. China.)
Abstract	1,8dihydroxy3acetyl6methyl9,10 anthraquinone (DAMA) was synthesized from emodin. In the present study, the activity and the oncosislike mechanism of DAMAenhanced nasopharyngeal carcinoma (NPC) cell sensitivity to ionizing radiation was examined. The results demonstrated that DAMA has a 1.46fold radiosensitisation activity for nasopharyngeal carcinoma CNE 1 cells with a noncytotoxic concentration of 10 µg/ml DAMA combined with 2 Gy. Following treatment of DAMA combined with radiation, CNE1 cells revealed severe cytoplasmic swelling and vacuolization, swollen mitochondria and dilation of the nuclei without chromatin condensation, yielding a typical morphology of oncosis. Oncosisrelated gene expression of ATP synthase F0 subunit 6, chromatin modifying protein 6 and cyclophilin D mRNA increased significantly in the 8 Gy radiation group and the 2 Gy radiation combined with DAMA group. A significant decrease of ATP synthase protein 8 mRNA was observed and the levels of intracellular ATP were also reduced. In addition, the levels of intracellular Ca2+ were increased. In conclusion, DAMA is a potent radiation sensitizer in nasopharyngeal carcinoma cells and mediates its radiosensitisation via oncosis.
ISSN	17912997
e-ISSN	17913004
Journal	Molecular Medicine Reports
Issue Number	2
Volume Number	10
Language	English
Publisher	Spandidos Publications
Publisher Date	2014-08-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Anthraquinones Toxicity Apoptosis Drug Effects Radiation-sensitizing Agents Adenosine Triphosphate Metabolism Chemistry Radiation Effects Calcium Cell Line, Tumor Cell Nucleus Ultrastructure Cyclophilins Genetics Endosomal Sorting Complexes Required For Transport Gamma Rays Membrane Potential, Mitochondrial Mitochondria Mitochondrial Proton-translocating Atpases Nasopharyngeal Neoplasms Pathology Organelles Research Support, Non-u.s. Gov't Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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