NDLI: microRNA25 promotes osteosarcoma cell proliferation by targeting the cellcycle inhibitor p27.

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microRNA25 promotes osteosarcoma cell proliferation by targeting the cellcycle inhibitor p27.

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microRNA25 promotes osteosarcoma cell proliferation by targeting the cellcycle inhibitor p27.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wang, Zhe Wang, Ming-Hui Wang, Xiu-Hui Cai, Pan
Description	Author Affiliation: Wang XH ( Department of Orthopaedics, Pudong New Area Zhoupu Hospital, Shanghai 201318, P.R. China.); Cai P ( Department of Orthopaedics, Pudong New Area Zhoupu Hospital, Shanghai 201318, P.R. China.); Wang MH ( Department of Orthopaedics, Pudong New Area Zhoupu Hospital, Shanghai 201318, P.R. China.); Wang Z ( Clinical Medical College, China Medical University, Shenyang, Liaoning 110001, P.R. China.)
Abstract	An increasing body of evidence indicates that microRNAs (miRNAs), a class of small noncoding RNAs, are often aberrantly expressed in human osteosarcoma. This study aimed to investigate the effects of miR25 and to identify its potential target genes in osteosarcoma (OS) cells. First, the expression of miR25 was detected by reverse transcriptionquantitative polymerase chain reaction (RT-qPCR), which revealed a significant upregulation of miR25 in osteosarcoma tissues compared to the adjacent healthy tissues. To investigate the role of miR25 in osteosarcoma cell proliferation, the miR25 precursor was next transfected into Saos2 and U2OS cells. Overexpression of miR25 promoted cell proliferation in vitro and tumor growth in a xenograft mouse model. In addition, our results revealed that the protein expression of p27, a cellcycle inhibitor, is negatively regulated by miR25. Restoring the p27 level in miR25overexpressing cells reversed the enhancing effect of miR25 on cell proliferation. Therefore, miR25 may act as an oncomiRNA in osteosarcoma, which provides new perspectives in cancer treatment strategies based on molecular targeting.
ISSN	17912997
e-ISSN	17913004
Journal	Molecular Medicine Reports
Issue Number	2
Volume Number	10
Language	English
Publisher	Spandidos Publications
Publisher Date	2014-08-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Bone Neoplasms Genetics Cyclin-dependent Kinase Inhibitor P27 Metabolism Micrornas Osteosarcoma 3' Untranslated Regions Animals Pathology Cell Line, Tumor Cell Proliferation Chemistry Mice Mice, Inbred Balb C Mice, Nude Sequence Alignment Transplantation, Heterologous Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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