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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kim, Sung Zoo Park, Byoung Hyun Kim, Soo Mi Cho, Chong Gu Noh, Hye Jung Kim, Sun Young |
| Description | Author Affiliation: Park BH ( Department of Internal Medicine, Medical School, Wonkwang University, Iksan, Jeonbuk 570749, Republic of Korea.); Kim SY ( Department of Physiology, Medical School, Institute for Medical Sciences, Chonbuk National University, Jeonju, Jeonbuk 561180, Republic of Korea.); Kim SM ( Department of Physiology, Medical School, Institute for Medical Sciences, Chonbuk National University, Jeonju, Jeonbuk 561180, Republic of Korea.); Noh HJ ( Department of Internal Medicine, Medical School, Wonkwang University, Iksan, Jeonbuk 570749, Republic of Korea.); Cho CG ( Department of Internal Medicine, Medical School, Wonkwang University, Iksan, Jeonbuk 570749, Republic of Korea.); Kim SZ ( Department of Physiology, Medical School, Institute for Medical Sciences, Chonbuk National University, Jeonju, Jeonbuk 561180, Republic of Korea.) |
| Abstract | Dendroaspis natriuretic peptide (DNP) shares a functionally important sequence homology with other natriuretic peptides. However, the characteristics of DNP and its receptor in the context of diabetes remafin to be fully elucidated. In the present study, alterations in the plasma levels and tissue contents of DNP and the properties of its receptor in diabetic rats, induced by streptozotocin (STZ) injection, were investigated. The plasma levels of DNP were 90.01 ± 4.12 and 196.68 ± 5.60 pg/ml in the control and STZ-induced diabetic rats, respectively. The tissue contents of DNP in the cardiac atrium, ventricle, renal cortex and inner medulla of the STZ-induced diabetic rats were also significantly increased compared with the control rats. Specific (125)I-DNP-binding sites were located predominantly in the glomeruli and inner medulla of the rat kidney. In the glomeruli of the kidney, the apparent dissociation constants (Kd) of (125)I-DNP in the control and STZ-induced diabetic rats were 0.41 ± 0.03 and 0.56 ± 0.06 nM, respectively. The maximum binding capacities (Bmax) of (125)I-DNP in control and STZ-induced diabetic rats were 2.98 ± 0.21 and 6.22 ± 1.06 fmol/mg protein, respectively. However, no differences were observed in the apparent Kd and Bmax of (125)I-DNP in the inner medulla of the kidney between the control and STZ-induced diabetic rats. In the glomerular and inner medullary kidney membranes, DNP stimulated the production of cyclic guanosine monophosphate (cGMP) in a dose-dependent manner. The magnitude of cGMP production in glomerular membranes was greater in the STZ-induced diabetic rats, whereas the magnitude of cGMP production in the inner medullary membranes was lower in the STZ-induced diabetic rats compared with the control rats. These results indicated that STZ-induced diabetes modulate DNP and its receptor, and also suggested that modulation of the DNP system is involved in the renal function of diabetic animals via the intracellular domain of the kidney NP receptor. |
| ISSN | 17912997 |
| e-ISSN | 17913004 |
| Journal | Molecular Medicine Reports |
| Issue Number | 2 |
| Volume Number | 12 |
| Language | English |
| Publisher | Spandidos Publications |
| Publisher Date | 2015-08-01 |
| Publisher Place | Greece |
| Access Restriction | Open |
| Subject Keyword | Diabetes Mellitus, Experimental Pathology Elapid Venoms Blood Peptides Animals Binding Sites Cyclic Gmp Metabolism Chemically Induced Heart Atria Heart Ventricles Iodine Radioisotopes Chemistry Kidney Glomerulus Kidney Medulla Protein Binding Rats, Sprague-dawley Streptozocin Toxicity Research Support, Non-u.s. Gov't Discipline Molecular Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology |
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