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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kim, Bum Hoi Han, Hyoung-Min Lee, Hai Woong Kim, Seung-Ju Kim, Jong-Sik Lee, Yong Tae Kang, Kyung-Hwa |
| Description | Author Affiliation: Han HM ( Department of Physiology, College of Korean Medicine, DongEui University, Busan 614851, Republic of Korea.); Kim SJ ( Department of Physiology, College of Korean Medicine, DongEui University, Busan 614851, Republic of Korea.); Kim JS ( Department of Anatomy, College of Medicine, Kosin University, Busan 602703, Republic of Korea.); Kim BH ( Department of Anatomy, College of Korean Medicine, DongEui University, Busan 614851, Republic of Korea.); Lee HW ( Department of Public Health, College of Korean Medicine, DongEui University, Busan 614851, Republic of Korea.); Lee YT ( Department of Physiology, College of Korean Medicine, DongEui University, Busan 614851, Republic of Korea.); Kang KH ( Department of Physiology, College of Korean Medicine, DongEui University, Busan 614851, Republic of Korea.) |
| Abstract | Artemisia argyi Folium has been used to treat skin diseases, including eczema and dermatitis, in South Korean medicine. The present study investigated the curative effects of Artemisia argyi Folium extract (AAFE) on 2,4dinitrochlorobenzene (DNCB)induced atopic dermatitis (AD)like skin lesions in a BALB/c mouse model. Briefly, the dorsal skin of the BALB/c mice was sensitized three times with DNCB, whereas the ears were challenged twice. Repeated treatment with DNCB induced ADlike lesions. The effects of AAFE on ADlike lesions were evaluated by clinical observation, histopathological analysis, immunohistochemistry and enzymelinked immunosorbent assay. In addition, reverse transcriptionpolymerase chain reaction and western blotting were performed. Treatment with AAFE reduced ADlike lesions, as determined by clinical observation, histopathological analysis, and detection of the serum levels of histamine, immunoglobulin E and cytokines. With regards to its mechanism of action, AAFE inhibited the phosphorylation of Lck/yesrelated novel tyrosine kinase (Lyn), spleen tyrosine kinase (Syk), mitogenactivated protein kinases (MAPKs), phosphoinositide 3kinase (PI3K)/Akt and IκB , which have essential roles in the production of various cytokines in lymph nodes. The suppressive activity of AAFE may be due to the inhibition of a series of immunopathological events, including the release of proinflammatory cytokines. The results of the present study strongly suggest that AAFE exerts an antiAD effect by inhibiting the Lyn, Syk, MAPKs, PI3K/Akt and IκB pathways. Therefore, AAFE may be considered an effective herbal remedy for the treatment of AD. |
| ISSN | 17912997 |
| e-ISSN | 17913004 |
| Journal | Molecular Medicine Reports |
| Issue Number | 4 |
| Volume Number | 14 |
| Language | English |
| Publisher | Spandidos Publications |
| Publisher Date | 2016-10-01 |
| Publisher Place | Greece |
| Access Restriction | Open |
| Subject Keyword | Discipline Molecular Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology |
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