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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Luo, Haoxuan Deng, Liuxiang Chen, Zexiong Sun, Baoguo Zhang, Shijun |
| Description | Author Affiliation: Sun B ( Department of Traditional Chinese Medicine, First Affiliated Hospital, Sun Yatsen University, Guangzhou, Guangdong 510080, P.R. China.); Luo H ( Department of Traditional Chinese Medicine, First Affiliated Hospital, Sun Yatsen University, Guangzhou, Guangdong 510080, P.R. China.); Deng L ( Department of Traditional Chinese Medicine, First Affiliated Hospital, Sun Yatsen University, Guangzhou, Guangdong 510080, P.R. China.); Zhang S ( Department of Traditional Chinese Medicine, First Affiliated Hospital, Sun Yatsen University, Guangzhou, Guangdong 510080, P.R. China.); Chen Z ( Department of Traditional Chinese Medicine, First Affiliated Hospital, Sun Yatsen University, Guangzhou, Guangdong 510080, P.R. China.) |
| Abstract | Various studies have investigated hepatic carcinoma cachexia, however, there is little published information regarding the effect of Chinese Medicine carcinoma cachexia. The present study was performed to investigate the effect of modified Chinese herbal compound jianpijiedu (MJPJD) on a mouse model of ascitesinduced hepatic carcinoma cachexia. C57BL/6 mice were randomized to five groups: Control (Group A); xenograft tumor (Group B); low concentration of MJPJD (Group C); high concentration of MJPJD (Group D) and medroxyprogesterone (MPA) combined with indometacin (IND; Group E). The mouse model of ascitesinduced hepatic carcinoma cachexia was established by abdominal injection of H22 hepatic carcinoma cells. Subsequently, the body weight, food intake and gastrocnemius weight were recorded, and the levels of interleukin (IL)l , IL6, tumor necrosis factor (TNF ) in ascites were detected by enzymelinked immunosorbent assay. The protein expression levels of muscle RINGfinger protein1 (MURF1) and atrogin 1 were detected by western blotting and immunohistochemistry, and the mRNA levels in gastrocnemius were detected by reverse transcriptionquantitative polymerase chain reaction. Compared with the xenograft tumor group, the administration of MJPJD inhibited the increase in body weight and the volume of ascites, the consumption of gastrocnemius was reduced, the net weight of ascites was maintained, the food intake was enhanced and the levels of the cytokines ILl , IL6, TNF in ascites and the levels of MURF1 and atrogin 1 proteins were reduced. These results indicated that MJPJD delays the pathological process of ascitesinduced hepatic carcinoma cachexia, and the mechanism of action may be correlated with a reduction in the levels of ILl , IL6, TNF and inhibiting the activation of the ubiquitin proteosome pathway. |
| ISSN | 17912997 |
| e-ISSN | 17913004 |
| Journal | Molecular Medicine Reports |
| Issue Number | 4 |
| Volume Number | 14 |
| Language | English |
| Publisher | Spandidos Publications |
| Publisher Date | 2016-10-01 |
| Publisher Place | Greece |
| Access Restriction | Open |
| Subject Keyword | Discipline Molecular Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology |
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