NDLI: Oxidative stress in keratoconus?

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Oxidative stress in keratoconus?

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Oxidative stress in keratoconus?

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Arnal, Emma Romero, Francisco Javier Johnsen-Soriano, Siv Peris-Martínez, Cristina Menezo, Jose Luis
Description	Country affiliation: Spain Author Affiliation: Arnal E ( Fundación Oftalmológica del Mediterráneo, Valencia, Spain.)
Abstract	PURPOSE: The purpose of this study was to establish the alterations of oxidative stress-related markers in keratoconus (KC) corneas. METHODS: A total of 6 healthy and 11 ectatic corneas (7 KC and 4 post-LASIK) were studied. Different oxidative stress-related markers were determined to assess their implication in the KC pathophysiology. Total antioxidant capacity and total nitrites present in the samples were assayed. Furthermore, lipid peroxidation products and the glutathione contents were determined, together with 4-hydroxynonenal (4-HNE) immunohistochemistry, to establish the relationship between KC and oxidative stress. RESULTS: The antioxidant capacity and glutathione content in KC corneas were decreased significantly when compared with healthy corneas. Moreover, the total nitrites and lipid peroxidation were significantly elevated in the corneas with KC when compared with the controls. There was a statistically significant difference in the amount of HNE-positive cells in KC corneas when compared with healthy corneas by immunohistochemistry. Post-LASIK ectatic corneas and KC corneas showed similar results. CONCLUSIONS: The increased levels of oxidative stress markers and the decreased antioxidant capacity and antioxidant defenses in KC corneas, as well as in the post-LASIK ectatic corneas, indicate that oxidative stress might be involved in the development of this disease and may provide new insights for its prevention and treatment in the future.
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	12
Volume Number	52
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2011-11-04
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antioxidants Metabolism Keratoconus Physiopathology Lipid Peroxidation Physiology Oxidative Stress Aldehydes Biological Markers Dilatation, Pathologic Glutathione Surgery Keratomileusis, Laser In Situ Nitrites Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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