NDLI: Role of connective tissue growth factor in the retinal vasculature during development and ischemia.

Please wait, while we are loading the content...

Year: 2017 Volume: 58

Year: 2016 Volume: 57

Year: 2015 Volume: 56

Year: 2014 Volume: 56

Year: 2014 Volume: 55

Year: 2013 Volume: 54

Year: 2012 Volume: 53

Year: 2011 Volume: 52

Year: 2011 Volume: 52 Issue: 13

Year: 2011 Volume: 52 Issue: 12

Reproducibility of cornea measurements in anterior segment OCT images of normal eyes and eyes with bullous keratopathy analyzed with the Zhongshan Assessment Program.

In vivo gene expression profiling of retina postintravitreal injections of dexamethasone and triamcinolone at clinically relevant time points for patient care.

Induction of retinal pigment epithelial cells from monkey iPS cells.

Prevalence and characteristics of primary angle-closure diseases in a rural adult Chinese population: the Handan Eye Study.

Long-term follow-up of the human phenotype in three siblings with cone dystrophy associated with a homozygous p.G461R mutation of KCNV2.

Endothelial cell decay after descemet's stripping automated endothelial keratoplasty and top hat penetrating keratoplasty.

Retinal Pathway Origins of the Pattern Electroretinogram (PERG)

Anterior chamber angle imaging with swept-source optical coherence tomography: an investigation on variability of angle measurement.

Miniaturized high-intensity focused ultrasound device in patients with glaucoma: a clinical pilot study.

Logarithmic transformation of spectral-domain optical coherence tomography data in uveitis-associated macular edema.

Suboptimal image focus broadens retinal vessel caliber measurement.

Rasch analysis of the Ocular Surface Disease Index (OSDI).

Retinas of the diurnal rodent Arvicanthis ansorgei are highly resistant to experimentally induced stress and degeneration.

Human retinal pigment epithelium cells as functional models for the RPE in vivo.

Hypoxia-regulated retinal glial cell-specific promoter for potential gene therapy in disease.

Histopathology of the trabecular meshwork and Schlemm's canal in primary angle-closure glaucoma.

Expression and functional roles of caspase-5 in inflammatory responses of human retinal pigment epithelial cells.

Substance P in the corneal stroma regulates the severity of herpetic stromal keratitis lesions.

Independent impact of area-level socioeconomic measures on visual impairment.

Oxidative stress in keratoconus?

Role of connective tissue growth factor in the retinal vasculature during development and ischemia.

Egr1 expression is induced following glatiramer acetate immunotherapy in rodent models of glaucoma and Alzheimer's disease.

Neurotransmitter influence on human meibomian gland epithelial cells.

Measurement of ocular fundus pulsation in healthy subjects using a novel Fourier-domain optical coherence tomography.

Supplementation with all three macular carotenoids: response, stability, and safety.

Quantitative evaluation of changes in eyeball shape in emmetropization and myopic changes based on elliptic fourier descriptors.

High glucose induces mitochondrial morphology and metabolic changes in retinal pericytes.

Gene expression changes in steroid-induced IOP elevation in bovine trabecular meshwork.

Relationships between visual field sensitivity and spectral absorption properties of the neuroretinal rim in glaucoma by multispectral imaging.

Increased proliferation and replicative lifespan of isolated human corneal endothelial cells with L-ascorbic acid 2-phosphate.

Disease course of patients with unilateral pigmentary retinopathy.

Effects of age, sex, and axial length on the three-dimensional profile of normal macular layer structures.

Barriers to low vision rehabilitation: the Montreal Barriers Study.

IOP-induced lamina cribrosa deformation and scleral canal expansion: independent or related?

Effect of controlled adverse chamber environment exposure on tear functions in silicon hydrogel and hydrogel soft contact lens wearers.

Morphologic choroidal and scleral changes at the macula in tilted disc syndrome with staphyloma using optical coherence tomography.

Role of the IL-6 classic- and trans-signaling pathways in corneal sterile inflammation and wound healing.

Following EAU recovery there is an associated MC5r-dependent APC induction of regulatory immunity in the spleen.

Persistent inhibition of oxygen-induced retinal neovascularization by anthrax lethal toxin.

Ocular responses and visual performance after emergent acceleration stress.

The sand rat, Psammomys obesus, develops type 2 diabetic retinopathy similar to humans.

Diabetic retinopathy and damage to mitochondrial structure and transport machinery.

Quantifying nystagmus in infants and young children: relation between foveation and visual acuity deficit.

Retinal pericytes inhibit activated T cell proliferation.

Central areolar choroidal dystrophy (CACD) and age-related macular degeneration (AMD): differentiating characteristics in multimodal imaging.

Complement factor D in age-related macular degeneration.

Variations in eye volume, surface area, and shape with refractive error in young children by magnetic resonance imaging analysis.

Role of mitochondria biogenesis in the metabolic memory associated with the continued progression of diabetic retinopathy and its regulation by lipoic acid.

Corneal penetration of topical and subconjunctival bevacizumab.

Vasoinhibin gene transfer by adenoassociated virus type 2 protects against VEGF- and diabetes-induced retinal vasopermeability.

Autoreactive antibodies and loss of retinal ganglion cells in rats induced by immunization with ocular antigens.

Age-related retinal function changes in albino and pigmented rats.

Nonlinear optical macroscopic assessment of 3-D corneal collagen organization and axial biomechanics.

Ectopic proliferation contributes to retinal dysplasia in the juvenile zebrafish patched2 mutant eye.

Longitudinal and simultaneous imaging of retinal ganglion cells and inner retinal layers in a mouse model of glaucoma induced by N-methyl-D-aspartate.

Association of elastin gene polymorphism to age-related macular degeneration and polypoidal choroidal vasculopathy.

Vision-related quality of life in patients with ocular chemical burns.

Functional loss in the magnocellular and parvocellular pathways in patients with optic neuritis.

Multiplex sequencing of seven ocular herpes simplex virus type-1 genomes: phylogeny, sequence variability, and SNP distribution.

The perceptual consequences of interocular suppression in amblyopia.

Visual cortical function in very low birth weight infants without retinal or cerebral pathology.

Equivalence of biomechanical changes induced by rapid and standard corneal cross-linking, using riboflavin and ultraviolet radiation.

Analysis and comparison of proteomic profiles of tear fluid from human, cow, sheep, and camel eyes.

Association between ocular dominance and spherical/astigmatic anisometropia, age, and sex: analysis of 10,264 myopic individuals.

FGF-2- and TGF-ß1-induced downregulation of lumican and keratocan in activated corneal keratocytes by JNK signaling pathway.

Ocular surface epithelial thickness evaluation with spectral-domain optical coherence tomography.

Lamellar macular hole: a clinicopathologic correlation of surgically excised epiretinal membranes.

Validation and reliability of the VF-14 questionnaire in a German population.

Phenotypic and genotypic characterization of coagulase negative staphylococci (CoNS) other than Staphylococcus epidermidis isolated from ocular infections.

Can clinical signs of trachoma be used after multiple rounds of mass antibiotic treatment to indicate infection?

High-throughput retina-array for screening 93 genes involved in inherited retinal dystrophy.

A novel mechanism of increased infections in contact lens wearers.

Active Immunization with Pneumolysin versus 23-Valent Polysaccharide Vaccine for Streptococcus pneumoniae Keratitis.

Insight into the Role of $Ca^{2+}-Binding$ Protein 5 in Vesicle Exocytosis

Central retinal function as measured by the multifocal electroretinogram and flicker perimetry in early age-related macular degeneration.

X-linked retinoschisis: RS1 mutation severity and age affect the ERG phenotype in a cohort of 68 affected male subjects.

Microglia-mediated IGF-I neuroprotection in the rd10 mouse model of retinitis pigmentosa.

A novel bisretinoid of retina is an adduct on glycerophosphoethanolamine.

Doxycycline enhances the inhibitory effects of bevacizumab on corneal neovascularization and prevents its side effects.

Automated discovery and quantification of image-based complex phenotypes: a twin study of drusen phenotypes in age-related macular degeneration.

Disruption of the retinal parafoveal capillary network in type 2 diabetes before the onset of diabetic retinopathy.

New grading criteria allow for earlier detection of geographic atrophy in clinical trials.

Patient-specific computational modeling of keratoconus progression and differential responses to collagen cross-linking.

Extracellular matrix elasticity modulates TGF-ß-induced p38 activation and myofibroblast transdifferentiation in human tenon fibroblasts.

Roles of AMP-activated protein kinase in diabetes-induced retinal inflammation.

Associations between genetic polymorphisms of insulin-like growth factor axis genes and risk for age-related macular degeneration.

Polarized distribution of heme transporters in retinal pigment epithelium and their regulation in the iron-overload disease hemochromatosis.

Cross-linking with ultraviolet-a and riboflavin reduces corneal permeability.

Beyond AREDS: is there a place for antioxidant therapy in the prevention/treatment of eye disease?

VEGF and PEDF secretion in ARPE-19 and fhRPE cells.

Predictors of visual acuity in macular edema.

Will the BEAT-ROP study results really beat ROP?

Year: 2011 Volume: 52 Issue: 11

Year: 2011 Volume: 52 Issue: 10

Year: 2011 Volume: 52 Issue: 9

Year: 2011 Volume: 52 Issue: 8

Year: 2011 Volume: 52 Issue: 7

Year: 2011 Volume: 52 Issue: 6

Year: 2011 Volume: 52 Issue: 5

Year: 2011 Volume: 52 Issue: 4

Year: 2011 Volume: 52 Issue: 3

Year: 2011 Volume: 52 Issue: 2

Year: 2011 Volume: 52 Issue: 1

Year: 2010 Volume: 51

Year: 2009 Volume: 50

Year: 2008 Volume: 49

Role of connective tissue growth factor in the retinal vasculature during development and ischemia.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Xia, Huiming Liu, Jianwen Shenoy, Anitha K. Scott, Edward W. Pi, Liya Hauswirth, William W.
Description	Country affiliation: United States Author Affiliation: Pi L ( Program in Stem Cell Biology and Regenerative Medicine, University of Florida, PO Box 100201, Gainesville, FL 32610, USA. lpi@ufl.edu)
Abstract	PURPOSE: To investigate the function of connective tissue growth factor (CTGF), a matricellular protein of the CCN (Cyr61/CTGF/Nov) family, in retinal vasculature during development and ischemia. METHODS: CTGF expression was determined using RT-PCR, immunohistochemistry, and transgenic mice carrying CTGF promoter-driven-GFP. CTGF antibody was intraocularly injected into neonates at postnatal day (P)2, and its effect on retinal angiogenesis was analyzed at P4. Transgenic animals expressing GFP regulated by the glial fibrillary acidic protein promoter were used for astrocyte visualization. Retinal vascular occlusion was introduced by rose Bengal and laser photocoagulation on chimeric mice that were reconstituted with GFP+ bone marrow cells. Vascular repair in response to VEGF-A and CTGF was analyzed. RESULTS: A temporal increase in CTGF at both mRNA and protein levels was observed in the ganglion cell layer and inner nuclear layer during development. Endothelial cells and pericytes were identified as the main cellular sources of CTGF during retinal angiogenesis. CTGF stimulated the migration of astrocytes, retinal endothelial cells, and pericytes in vitro. Inhibition of CTGF by specific antibody affected vascular filopodial extension, growth of the superficial vascular plexus, and astrocyte remodeling. In adult mice, CTGF was prominently expressed in the perivascular cells of arteries. CTGF activated bone marrow-derived perivascular cells and promoted fibrovascular membrane formation in the laser-induced adult retinopathy model. CONCLUSIONS: CTGF is expressed in vascular beds and acts on multiple cell types. It is important for vessel growth during early retinal development and promotes the fibrovascular reaction in murine retinal ischemia after laser injury.
ISSN	01460404
e-ISSN	15525783
DOI	10.1167/iovs.11-7870
Journal	Investigative Opthalmology & Visual Science
Issue Number	12
Volume Number	52
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2011-11-07
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Connective Tissue Growth Factor Physiology Ischemia Physiopathology Retinal Diseases Retinal Vessels Growth & Development Animals Antibodies Pharmacology Astrocytes Cytology Cell Movement Cells, Cultured Genetics Immunology Disease Models, Animal Endothelial Cells Green Fluorescent Proteins Pathology Mice Mice, Inbred C57bl Mice, Transgenic Neovascularization, Physiologic Pericytes Retina Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in