NDLI: Role of the IL-6 classic- and trans-signaling pathways in corneal sterile inflammation and wound healing.

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Role of the IL-6 classic- and trans-signaling pathways in corneal sterile inflammation and wound healing.

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Role of the IL-6 classic- and trans-signaling pathways in corneal sterile inflammation and wound healing.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Matsuda, Hironori Murakami, Akira Ebihara, Nobuyuki Matsuda, Akira Nakamura, Shinji
Description	Country affiliation: Japan Author Affiliation: Ebihara N ( Department of Ophthalmology, Juntendo University School of Medicine, Tokyo, Japan. ebihara@juntendo.ac.jp)
Abstract	PURPOSE: To investigate the role of the IL-6 classic- and trans-signaling pathways in corneal sterile inflammation and wound healing. METHODS: To assess the production of inflammatory molecules by corneal fibroblasts treated with supernatant derived from necrotic corneal epithelial cells, the authors used an antibody array. Expressions of membrane IL-6 receptor (mIL-6R) and soluble IL-6R (SIL-6R) by fibroblasts and epithelial cells were detected with flow cytometry and RT-PCR. Expressions of signal transducer and activator of transcription 3 (STAT3), vascular endothelial growth factor (VEGF), and monocyte chemotactic protein-1 (MCP-1) by fibroblasts stimulated with IL-6 alone or IL-6/SIL-6R were determined by ELISA. The effect of IL-6 or IL-6/SIL-6R on epithelial cell migration was investigated in vitro by the scratch assay, whereas expressions of IL-6R and S100 A4 in the corneas of mice were detected by immunohistochemistry after incision of the corneal stroma. RESULTS: IL-1 derived from necrotic corneal epithelial cells induced the production of IL-6 by corneal fibroblasts. mIL-6R and SIL-6R mRNAs were expressed by both types of cells, although IL-6R protein at the cell surface was expressed only by epithelial cells. Expression of gp130 was detected in both types of cells. Activation of the IL-6 trans-signaling pathway induced the phosphorylation of STAT3, resulting in an increase of VEGF and MCP-1 production by corneal fibroblasts. Activation of the IL-6 classic-signaling pathway promoted the migration of corneal epithelial cells. IL-6R expression was also detected in activated fibroblasts and basal cells of the epithelium during the processes of wound healing in vivo. CONCLUSIONS: The IL-6 classic- and trans-signaling pathways have an important role in corneal sterile inflammation and wound healing.
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	12
Volume Number	52
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2011-11-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Corneal Keratocytes Immunology Epithelium, Corneal Interleukin-6 Metabolism Keratitis Signal Transduction Wound Healing Cell Movement Physiology Chemokine Ccl2 Pathology Cytokine Receptor Gp130 Epithelial Cells Genetics Necrosis Phosphorylation Primary Cell Culture Receptors, Interleukin-6 Stat3 Transcription Factor Vascular Endothelial Growth Factor A Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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