NDLI: Genetic variants on 17q21 are associated with asthma in a Han Chinese population.

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Genetic variants on 17q21 are associated with asthma in a Han Chinese population.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Li, F-X Wu, Y-S Tan, J-Y Wu, D. Li, M. Yang, X-X
Spatial Coverage	China
Description	Author Affiliation: Li FX ( School of Biotechnology, Southern Medical University, Guangzhou, PR China.)
Abstract	A genome-wide study has shown an association between SNPs located on 17q21 and asthma. Such associations have been identified in several populations, but little is known about the Han Chinese population. We conducted a case-control study in a Han Chinese population to investigate the relationship between SNPs located on 17q21 and asthma; 241 asthmatic patients and 212 healthy controls were recruited from the outpatient clinics of the Nanfang Hospital, Guangdong Province, southern China. We genotyped six SNPs (rs8067378, rs8069176, rs2305480, rs4795400, rs12603332, and rs11650680) located on 17q21 with the Sequenom MassARRAY iPLEX platform. For two of these six loci (rs2305480 and rs8067378), there was evidence of association with asthma, and there was a weak association of asthma with rs8069176. We confirm that genetic variants on 17q21 are associated with asthma in the Han Chinese population.
e-ISSN	16765680
Journal	Genetics and Molecular Research
Issue Number	1
Volume Number	11
Language	English
Publisher	Fundação de Pesquisas Científicas de Ribeirão Preto
Publisher Date	2012-02-10
Publisher Place	Brazil
Access Restriction	Open
Subject Keyword	Asthma Genetics Chromosomes, Human, Pair 17 Neoplasm Proteins Polymorphism, Single Nucleotide Adolescent Pathology Case-control Studies Ethnology Ethnic Groups Genetic Predisposition To Disease Genotype Research Support, Non-u.s. Gov't Discipline Genetics Discipline Molecular Biology Discipline Bioinformatics
Content Type	Text
Resource Type	Article

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