NDLI: Genotoxicity, cytotoxicity and toxicological evaluation of whole plant extracts of the medicinal plant Phyllanthus niruri (Phyllanthaceae).

Please wait, while we are loading the content...

Year: 2016 Volume: 15

Year: 2016 Volume: 14

Year: 2015 Volume: 14

Year: 2014 Volume: 13

Year: 2013 Volume: 12

Year: 2012 Volume: 11

Year: 2012 Volume: 11 Issue: 4

Year: 2012 Volume: 11 Issue: 3

Year: 2012 Volume: 11 Issue: 2

Year: 2012 Volume: 11 Issue: 1

Combined analysis of the MspI and XbaI polymorphisms in intron 22 of the factor VIII gene for detection of hemophilia A in a Korean population.

Genetic diversity of Metrodorea nigra (Rutaceae) from a small forest remnant in Brazil assessed with microsatellite markers.

Bayesian inference to study genetic control of resistance to gray leaf spot in maize.

Food assimilated by two sympatric populations of the brown planthopper Nilaparvata lugens (Delphacidae) feeding on different host plants contaminates insect DNA detected by RAPD-PCR analysis.

Molecular characteristics and expression of calmodulin cDNA from the freshwater pearl mussel, Hyriopsis schlegelii.

An improved reverse dot hybridization for simple and rapid detection of adefovir dipivoxil-resistant hepatitis B virus.

Polymorphisms of the TIM-1 gene are associated with rheumatoid arthritis in the Chinese Hui minority ethnic population.

Prevalence of CYP2C9 and VKORC1 alleles in the Argentine population and implications for prescribing dosages of anticoagulants.

Sodium valproate inhibits MDA-MB-231 breast cancer cell migration by upregulating NM23H1 expression.

Association of T869C gene polymorphism of transforming growth factor-ß1 with low protein levels and anthropometric indices in osteopenia/osteoporosis postmenopausal Thai women.

Genotoxicity, cytotoxicity and toxicological evaluation of whole plant extracts of the medicinal plant Phyllanthus niruri (Phyllanthaceae).

Abnormal male meiosis explains pollen sterility in the polyploid medicinal plant Pinellia ternata (Araceae).

Cytomixis and meiotic abnormalities during microsporogenesis are responsible for male sterility and chromosome variations in Houttuynia cordata.

Karyotype analysis of mithun (Bos frontalis) and mithun bull x Brahman cow hybrids.

Multiplex PCR panel of microsatellite markers for the tambaqui, Colossoma macropomum, developed as a tool for use in conservation and broodstock management.

Circulatory microRNA-145 expression is increased in cerebral ischemia.

Immunohistochemical and molecular analysis of caveolin-1 expression in canine mammary tumors.

Carcass composition and meat quality of indigenous Yanan pigs of China.

Improved method for predicting protein fold patterns with ensemble classifiers.

A simple boiling-based DNA extraction for RAPD profiling of landfarm soil to provide representative metagenomic content.

Detection by denaturing gradient gel electrophoresis of ammonia-oxidizing bacteria in microcosms of crude oil-contaminated mangrove sediments.

Genetic and biochemical differentiation in Vitis vinifera (Kabarcik) populations grown at different altitudes in Coruh Valley.

Association between HLA-A and -B polymorphisms and susceptibility to Henoch-Schönlein purpura in Han and Mongolian children from Inner Mongolia.

Leaf morphological and genetic divergence in populations of Drimys (Winteraceae) in Chile.

Improved production of transgenic Dioscorea zingiberensis (Dioscoreaceae) by Agrobacterium tumefaciens-mediated transformation.

Analysis of genetic distance by SSR in waxy maize.

Association between Ser311Cys polymorphism in the dopamine D2 receptor gene and schizophrenia risk: a meta-analysis in Asian populations.

Genetic analysis of body weights of individually fed beef bulls in South Africa using random regression models.

Identification of actinomycete communities in Antarctic soil from Barrientos Island using PCR-denaturing gradient gel electrophoresis.

Genetic relationship of cowpea (Vigna unguiculata) varieties from Senegal based on SSR markers.

(Co)variance components and genetic parameters for growth traits in Arabi sheep using different animal models.

Philadelphia-negative chromosomal evolution during treatment for chronic myeloid leukemia.

Molecular characterization of the Andean blackberry, Rubus glaucus, using SSR markers.

Variation in DNA repair gene XRCC3 affects susceptibility to astrocytomas and glioblastomas.

Genetic variants on 17q21 are associated with asthma in a Han Chinese population.

Simple and rapid protocol for the isolation of PCR-amplifiable DNA from medicinal plants.

Position effect variegation and epigenetic modification of a transgene in a pig model.

Multiple variants of TERT and CLPTM1L constitute risk factors for lung adenocarcinoma.

Characterization of nine novel microsatellite loci for the Venus clam (Cyclina sinensis).

Characterization of Fusarium species section Liseola by restriction analysis of the IGS region.

Estimation of taurindicine hybridization of American Zebu cattle in Brazil.

A possible role of a cerebral energy gene in alcoholism.

Effects of the antipsoriatic drug dithranol on E2A and caspase-9 gene expression in vitro.

Isolation and characterization of polymorphic microsatellite loci from the invasive plant Solidago canadensis (Asteraceae).

Genetic variation and comparison of orchardgrass (Dactylis glomerata L.) cultivars and wild accessions as revealed by SSR markers.

Development and characterization of 70 novel microsatellite markers for the sea cucumber (Apostichopus japonicus).

Development of a species-specific sequence-characterized amplified region marker for roses.

Osteosarcoma arising from osteochondroma of the tibia: case report and cytogenetic findings.

Lack of association between Gly82Ser, 1704G/T and 2184A/G of RAGE gene polymorphisms and retinopathy susceptibility in Malaysian diabetic patients.

Frequency of human papillomavirus types 16, 18, 31, and 33 and sites of cervical lesions in gynecological patients from Recife, Brazil.

Gene expression profiles in the cerebellum of transgenic mice over expressing the human FMR1 gene with CGG repeats in the normal range.

Molecular cloning and tissue distribution of the Toll receptor in the black tiger shrimp, Penaeus monodon.

Identification of differentially expressed genes involved in early bolting of Angelica sinensis (Apiaceae).

Genetic diversity and differentiation in Camellia reticulata (Theaceae) polyploid complex revealed by ISSR and ploidy.

Establishment of an in vitro regeneration system for genetic transformation of selected sugarcane genotypes.

Genetic diversity in populations of Acrocomia aculeata (Arecaceae) in the northern region of Minas Gerais, Brazil.

DNA barcoding of Oryx leucoryx using the mitochondrial cytochrome C oxidase gene.

Fibroblast growth factor receptor 4 Gly388Arg polymorphism associated with severity of gallstone disease in a Chinese population.

Genetic diversity of Brazilian and introduced olive germplasms based on microsatellite markers.

Comparison of five DNA extraction methods for molecular analysis of Jerusalem artichoke (Helianthus tuberosus).

RT-qPCR assay on the vitamin D receptor gene in type 2 diabetes and hypertension patients in Turkey.

Comparison of efficiency of distance measurement methodologies in mango (Mangifera indica) progenies based on physicochemical descriptors.

Genetic diversity analysis of Bt cotton genotypes in Pakistan using simple sequence repeat markers.

Association of AFLP and SCAR markers with common leafspot resistance in autotetraploid alfalfa (Medicago sativa).

Piperine inhibits cytokine production by human peripheral blood mononuclear cells.

Phylogeny and evolution of Cervidae based on complete mitochondrial genomes.

Hemagglutinin protein of Asian strains of human influenza virus A H1N1 binds to sialic acid--a major component of human airway receptors.

Genetic diversity analysis of barley landraces and cultivars in the Shanghai region of China.

Polymorphisms of the ATP1A1 gene associated with mastitis in dairy cattle.

Optimization of factors affecting Agrobacterium-mediated transformation of Micro-Tom tomatoes.

DNA extraction from skins of wild (Hydrochoerus hydrochaeris and Pecari tajacu) and domestic (Sus scrofa domestica) species using a novel protocol.

Evaluation of wheat landrace genotypes for salinity tolerance at vegetative stage by using morphological and molecular markers.

High segregation distortion in maize B73 x teosinte crosses.

Intra-specific genetic diversity in wild olives (Olea europaea ssp cuspidata) in Hormozgan Province, Iran.

QTL analysis of percentage of grains with chalkiness in Japonica rice (Oryza sativa).

BDNF and DARPP-32 genes are not risk factors for schizophrenia in the Malay population.

Genetic variation in a wild population of the 'sleep' passion fruit (Passiflora setacea) based on molecular markers.

Downregulation of hsp22 gene expression in Drosophila melanogaster from sites located near chemical plants.

Sequence variants in the bovine PRDM16 gene associated with body weight in Chinese cattle breeds.

Isolation of high quality and polysaccharide-free DNA from leaves of Dimorphandra mollis (Leguminosae), a tree from the Brazilian Cerrado.

rDNA ITS sequences among morphotypes of Keratell cochlearis, Keratell quadrata and Brachionus forficula (Rotifera).

Production of human factor VIII-FL in 293T cells using the bicistronic MGMT(P140K)-retroviral vector.

Year: 2011 Volume: 10

Year: 2010 Volume: 9

Year: 2009 Volume: 8

Year: 2008 Volume: 7

Year: 2007 Volume: 6

Year: 2006 Volume: 5

Year: 2005 Volume: 4

Year: 2004 Volume: 3

Year: 2003 Volume: 2

Year: 2002 Volume: 1

Genotoxicity, cytotoxicity and toxicological evaluation of whole plant extracts of the medicinal plant Phyllanthus niruri (Phyllanthaceae).

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Addo, P. Nyarko, A. K. Gyan, B. Adjei, D. N. Adjei, S. Asare, G. A. Bugyei, K. Yahaya, E. S. Wiredu, E. K. Sittie, A.
Description	Country affiliation: Ghana Author Affiliation: Asare GA ( School of Allied Health Sciences, University of Ghana, Legon, Ghana. gasare@chs.edu.gh)
Abstract	Phyllanthus niruri is a medicinal plant (commonly known as stone breaker) found in the tropics and other parts of the world. It is known for its capacity to block the formation of calcium oxalate crystals and kidney stone formation in urolithiasis. This plant has been used to treat hyperglycemia, hypertension, pain, and mild cases of malaria. We examined the geno-, cyto- and overall toxicity of P. niruri whole plant ethanolic extract. The extract was administered as a single dose of 30 or 300 mg/kg to laboratory rats by gavage, accompanied by negative (0.9% saline) and positive (10 mg/mL N-ethyl-N-nitrosourea) controls that were injected intramuscularly 48 h after extract administration. The ratio of polychromatic (PCE)/normochromatic erythrocytes (NCE) from femur bone marrow was scored for genotoxicity. Cytotoxicity was determined using descending concentrations (0.2-0.0125 g/mL) of the extract incubated with peripheral blood mononuclear cells. Lactate dehydrogenase release from damaged cells was determined and the CC(50) calculated. Subchronic administration of the extract at 30 or 300 mg/kg was done for 90 days to determine general toxicity. PCE:NCE (%) for the extract and negative control was 63, compared to 168 (positive control). The CC(50) was 26.3 mg/mL and hepato-renal toxicity after subchronic extract administration was nil. We conclude that ethanol extract of P. niruri is not cytotoxic or genotoxic, and is generally non-toxic on subchronic administration.
e-ISSN	16765680
Journal	Genetics and Molecular Research
Issue Number	1
Volume Number	11
Language	English
Publisher	Fundação de Pesquisas Científicas de Ribeirão Preto
Publisher Date	2012-01-13
Publisher Place	Brazil
Access Restriction	Open
Subject Keyword	Phyllanthus Toxicity Plant Extracts Animals Calcium Oxalate Antagonists & Inhibitors Erythrocytes Drug Effects L-lactate Dehydrogenase Secretion Leukocytes, Mononuclear Mutagenicity Tests Plants, Medicinal Rats, Sprague-dawley Urinalysis Research Support, Non-u.s. Gov't Discipline Genetics Discipline Molecular Biology Discipline Bioinformatics
Content Type	Text
Resource Type	Article

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in