NDLI: CTLA-4 and CD86 genetic variants and haplotypes in patients with rheumatoid arthritis in southeastern China.

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CTLA-4 and CD86 genetic variants and haplotypes in patients with rheumatoid arthritis in southeastern China.

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CTLA-4 and CD86 genetic variants and haplotypes in patients with rheumatoid arthritis in southeastern China.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Liu, C-P Shen, Y. Xu, T. Jiang, J-A Wang, T. Liu, X-M Zhu, R-R Wu, M. Gao, L. Zhang, X-G
Spatial Coverage	China
Description	Country affiliation: China Author Affiliation: Liu CP ( Jiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University, Suzhou, China.)
Abstract	The cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and costimulatory molecule (CD80/CD86) genes are important susceptibility genes associated with autoimmune diseases. CTLA-4 polymorphisms have been found to be associated with various autoimmune diseases. However, the association data are inconsistent for rheumatoid arthritis (RA). We investigated the genetic association of CTLA-4 and CD86 polymorphisms with RA in a Chinese population. Four single nucleotide polymorphisms (SNPs) (rs5742909 and rs231775 in CTLA-4, and rs17281995 and rs1129055 in CD86) were genotyped in 213 patients with RA and 303 healthy controls using polymerase chain reaction-restriction fragment length polymorphism. The genotype and allele distributions of rs5742909 differ significantly between RA patients and controls (P < 0.05) and the dominant model was found to be the best inheritance model. Stratification studies showed that CTLA-4 gene polymorphisms were more significantly associated with rheumatoid factor-negative and anti-cyclic citrullinated peptide-negative subgroups in the southeastern Han Chinese population. We also found that the haplotype of 2 CTLA-4 SNPs showed significant association with the disease (P = 0.0025) with the T-A (OR = 1.88, 95%CI = 1.12-3.15) and T-G (OR = 3.45, 95%CI = 1.10-10.87) haplotypes being observed more frequently in cases than in controls. We failed to find any significant association of the 2 CD86 SNPs with RA. These results indicate that the polymorphisms of CTLA-4 (rs5742909) may be important genetic factors for RA risk in the southeastern Han Chinese population.
e-ISSN	16765680
Journal	Genetics and Molecular Research
Issue Number	2
Volume Number	12
Language	English
Publisher	Fundação de Pesquisas Científicas de Ribeirão Preto
Publisher Date	2013-04-25
Publisher Place	Brazil
Access Restriction	Open
Subject Keyword	Antigens, Cd86 Genetics Arthritis, Rheumatoid Ctla-4 Antigen Haplotypes Polymorphism, Single Nucleotide Alleles Immunology Autoantibodies Case-control Studies Gene Frequency Genotype Linkage Disequilibrium Peptides, Cyclic Rheumatoid Factor Research Support, Non-u.s. Gov't Discipline Genetics Discipline Molecular Biology Discipline Bioinformatics
Content Type	Text
Resource Type	Article

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