NDLI: Investigation of CTLA-4 and CD86 gene polymorphisms in Iranian patients with brucellosis infection.

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Investigation of CTLA-4 and CD86 gene polymorphisms in Iranian patients with brucellosis infection.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Eskandari-Nasab, Ebrahim Moghadampour, Mehdi Najibi, Habib Hadadi-Fishani, Mehdi
Spatial Coverage	Iran
Description	Author Affiliation: Eskandari-Nasab E ( Genetic of Non-Communicable Disease Research Center)
Abstract	The protective immune response against Brucella involves T-cell-mediated immunity. T-lymphocyte receptors, CD28 and cytotoxic T-lymphocyte-associated protein-4 (CTLA-4), bind the same ligands, CD80 (B7-1) and CD86 (B7-2) on antigen-presenting cells and regulate T cell activation. CD28 delivers stimulatory signals whereas CTLA-4 provides inhibitory signals for T cell activation. Here, we investigated the association of four polymorphisms in CTLA4 (+49A/G [rs231775] and -318 C/T [rs5742909]) and its ligand CD86 (+1057 G/A [rs1129055] and +2379G/C [rs17281995]) with brucellosis infection. The study included 153 Iranian patients with active brucellosis and 128 healthy individuals as the control group. Genotyping of the CTLA4 and CD86 variants was performed using tetra amplification refractory mutation system-polymerase chain reaction (T-ARMS-PCR) and PCR-restriction fragment length polymorphism analysis, respectively. It was found that the CTLA4 -318 CT genotype and T allele were present more frequently in cases than in controls and are therefore associated with an increased risk for brucellosis (-318 TT genotype; OR = 2.544, P = 0.002). Likewise, the CD86 +1057 GA and AA genotypes and A allele were associated with an increased risk of brucellosis (+1057 AA genotype; OR = 3.81, P = 0.001). However, no statistically significant difference between brucellosis patients and controls in the allele and genotype distributions of CTLA4, +49A/G (P = 0.859) and CD86, +2379G/C (P = 0.476) was found. In conclusion, CTLA4 -318 CT genotype and T allele and the CD86 +057 GA and AA genotypes and A allele play roles as risk factors for developing brucellosis infection in Iran.
File Format	HTM / HTML
ISSN	03855600
Issue Number	2
Volume Number	58
e-ISSN	13480421
Journal	Microbiology and Immunology
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2014-02-01
Publisher Place	Australia
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Microbiology Discipline Immunology Antigens, Cd86 Genetics Brucella Immunology Brucellosis Ctla-4 Antigen Polymorphism, Genetic Adolescent Adult Aged Alleles Diagnosis Case-control Studies Child Female Gene Frequency Genotype Haplotypes Humans Iran Linkage Disequilibrium Male Middle Aged Odds Ratio Retrospective Studies Young Adult Journal Article
Content Type	Text
Resource Type	Article
Subject	Virology Immunology Microbiology

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