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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Lee, H. Kwon, J. T. Lee, S. W. Kim, H. J. Kim, H. K. Lew, B. L. Kim, Y. O. Lee, S. Sim, W. Y. Cho, I. K. |
| Description | Author Affiliation: Kim HK ( Department of Clinical Pharmacology, College of Medicine, Soonchunhyang University, Cheonan, Republic of Korea.); Lee H ( Department of Clinical Pharmacology, College of Medicine, Soonchunhyang University, Cheonan, Republic of Korea.); Lew BL ( Department of Dermatology, College of Medicine, Kyung Hee University, Seoul, Republic of Korea.); Sim WY ( Department of Dermatology, College of Medicine, Kyung Hee University, Seoul, Republic of Korea.); Kim YO ( Development of Ginseng and Medical Plants Research Institute, Rural Administration, Eumseong, Republic of Korea.); Lee SW ( Development of Ginseng and Medical Plants Research Institute, Rural Administration, Eumseong, Republic of Korea.); Lee S ( Department of Integrative Plant Science, Chung-Ang University, Anseong, Republic of Korea.); Cho IK ( Department of Convergence Medical Science, Brain Korea 21 Plus Program, Institute of Korean Medicine, College of Oriental Medicine, Kyung Hee University, Seoul, Republic of Korea.); Kwon JT ( Department of Clinical Pharmacology, College of Medicine, Soonchunhyang University, Cheonan, Republic of Korea.); Kim HJ ( Department of Clinical Pharmacology, College of Medicine, Soonchunhyang University, Cheonan, Republic of Korea.) |
| Abstract | The transporter 1 ATP-binding cassette sub-family B (MDR/TAP) gene (TAP1) is located in the major histocompatibility complex class II region, and forms a heterodimer that plays a key role in endogenous antigen presentation pathways. Investigation of polymorphisms identified in these loci has revealed an association with several autoimmune disorders. Alopecia areata (AA) is a common autoimmune disease resulting from T cell-induced damage to hair follicles. The present study documents for the first time a comparison between the allelic and genotypic frequencies of TAP1 single nucleotide polymorphisms (SNPs) in patients with AA and those of a control group, using a direct sequencing method. Our results suggest an association between a promoter SNP (rs2071480) and susceptibility to this disease. |
| e-ISSN | 16765680 |
| Journal | Genetics and Molecular Research |
| Issue Number | 4 |
| Volume Number | 14 |
| Language | English |
| Publisher | Fundação de Pesquisas Científicas de Ribeirão Preto |
| Publisher Date | 2015-12-29 |
| Publisher Place | Brazil |
| Access Restriction | Open |
| Subject Keyword | Atp-binding Cassette Transporters Genetics Alopecia Areata Genetic Predisposition To Disease Hair Follicle Metabolism Polymorphism, Single Nucleotide Promoter Regions, Genetic Immunology Adolescent Alleles Ethnology Pathology Asian Continental Ancestry Group Case-control Studies Gene Expression Gene Frequency Genetic Loci T-lymphocytes Research Support, Non-u.s. Gov't Discipline Genetics Discipline Molecular Biology Discipline Bioinformatics |
| Content Type | Text |
| Resource Type | Article |
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