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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Pearce, Mark C. Gao, Zhiqiang Ting, Boon Ping Khan, Majad Yang, Yiyan Zhang, Jie Ying, Jackie Y. |
| Description | Country affiliation: Singapore Author Affiliation: Zhang J ( Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, #04-01, Singapore 138669, Singapore.) |
| Abstract | Herein we describe a novel signal amplification strategy for the development of ultrasensitive electrochemical immunosensors. The amplification strategy is based on platinum catalyzing a hydrogen evolution reaction. To demonstrate its practicality, the electrochemical signal enhancement strategy has been applied for the development of a novel prostate-specific antigen (PSA) immunosensor. The immunosensing protocol utilized a gold electrode with PSA capture antibodies bound to its surface via covalent bonding. After PSA was bound to the electrode surface, a secondary platinum nanoparticle-labeled detection antibody was used to complete the sandwich immunosensor. The resulting electrode was then dipped in a platinum developer solution containing 1 mM of PtCl4(2-), 0.1M of formate (reductant) and 0.5% Tween 80 (pH 6.5) to generate bare platinum catalysts in close proximity to the Au electrode surface through a seed-mediated nucleation and growth mechanism. The signal readout was obtained electrochemically via a Pt-catalyzed hydrogen evolution reaction in an acidic aqueous medium containing 10 mM of HCl and 1 M of KCl. A detection limit of 1 fg/ml was achieved. |
| ISSN | 09565663 |
| Issue Number | 2 |
| Volume Number | 26 |
| e-ISSN | 18734235 |
| Journal | Biosensors and Bioelectronics |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-10-15 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Biosensing Techniques Instrumentation Conductometry Electrodes Immunoassay Microchemistry Platinum Chemistry Prostate-specific Antigen Analysis Catalysis Equipment Design Equipment Failure Analysis Humans Male Staining And Labeling Methods Journal Article Research Support, Non-u.s. Gov't Discipline Biotechnology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nanoscience and Nanotechnology Medicine Biophysics Biomedical Engineering Biotechnology Electrochemistry |
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