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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Bhargava, Kalpana Kotamraju, Srigiridhar Karunakaran, Chandran Rajesh, Seenivasan Ilavazhagan, Govindaswamy Kanugula, Anantha Koteswararao |
| Description | Country affiliation: India Author Affiliation: Rajesh S ( Biomedical Research Laboratory, Department of Chemistry, VHNSN College, Virudhunagar 626 001, Tamil Nadu, India.) |
| Abstract | A novel highly sensitive biosensor for the direct and simultaneous determination of superoxide anion radical (O2-) and nitrite (NO2-) was developed by incorporation of carbon nanotube (CNT) solubilized in nafion in polypyrrole (PPy) matrix on Pt electrode followed by immobilization of Cu,ZnSOD (SOD1) on it. The CNT/PPy nanocomposite electrode enhanced the immobilization of SOD1 and promoted the electron transfer of SOD1 minimizing its fouling effect. The surface morphological images of PPy and CNT-PPy nanocomposite on Pt electrode were obtained by scanning electron microscopy exhibiting highly microporous structures. The electrochemical behavior of the biosensor investigated by cyclic voltammetry revealed that the SOD1 immobilized electrode showed characteristic of SOD1 quasi-reversible redox peaks with a formal potential of +0.065 V vs. Ag/AgCl. The biosensor exhibited a linear response over the concentration range from 0.1 to 750 µM, with a detection limit of 0.1±0.03 µM for O2- and a corresponding linear range of 0.5-2000 µM, with a detection limit of 0.5±0.025 µM for NO2-. In addition, the biosensor exhibited high sensitivity, good reproducibility and retained stability over 30 days. This modified electrode was quite effective not only in detecting O2- and NO2- independently but also determining the concentration of O2- and NO2- simultaneously in vitro and from cancer cells. |
| ISSN | 09565663 |
| Issue Number | 2 |
| Volume Number | 26 |
| e-ISSN | 18734235 |
| Journal | Biosensors and Bioelectronics |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-10-15 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Biosensing Techniques Instrumentation Conductometry Nanotubes, Carbon Chemistry Nitrites Analysis Polymers Pyrroles Superoxide Dismutase Superoxides Complex Mixtures Enzymes, Immobilized Equipment Design Equipment Failure Analysis Journal Article Research Support, Non-u.s. Gov't Discipline Biotechnology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nanoscience and Nanotechnology Medicine Biophysics Biomedical Engineering Biotechnology Electrochemistry |
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