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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Verkerk, J. M. Van Der Marel, G. A. Neefjes, J. J. Broxterman, H. J. Van Boom, J. H. Ploegh, H. L. |
| Description | Author Affiliation: Neefjes JJ ( Netherlands Cancer Institute, Amsterdam.) |
| Abstract | Recycling of a number of glycoproteins along the site of action of mannosidase I (the distal endoplasmic reticulum/cis-Golgi) was followed in several different cell lines. Treatment of cells with 1- deoxymannojirimycin (dMM) produced high mannose oligosaccharides at positions otherwise occupied by complex-type oligosaccharides in these glycoproteins. Conversion of high-mannose-type oligosaccharides to complex oligosaccharides of proteins initially synthesized in the presence of dMM was used as a marker for recycling of glycoproteins along the site of action of dMM. In contrast to findings reported by Snider and Rogers (Snider, M. D., and O. C. Rogers. 1986. J. Cell Biol. 103:265-275), removal of dMM did not result in reconversion of high- mannose oligosaccharides to complex-type sugars, even after prolonged periods of culture. We conclude that surface glycoproteins do not recycle through the cis-medial Golgi elements. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 1 |
| Volume Number | 107 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 1988-07-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Endoplasmic Reticulum Metabolism Glycoproteins Golgi Apparatus 1-Deoxynojirimycin Anti-Bacterial Agents Pharmacology Carcinoma, Hepatocellular Cell Line, Transformed Electrophoresis, Polyacrylamide Gel Enzymology Glucosamine Analogs & Derivatives HLA Antigens HLA-D Antigens Immunoassay Isoelectric Focusing Leukemia, Erythroblastic, Acute Liver Neoplasms Mannosidases Antagonists & Inhibitors Neuraminidase Receptors, Transferrin Drug Effects Transferrin Tumor Cells, Cultured Research Support, Non-U.S. Gov't Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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