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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Dustin, M. L. Springer, T. A. |
| Description | Author Affiliation: Dustin ML ( Laboratory of Membrane Immunochemistry, Dana-Farber Cancer Institute, Boston, Massachusetts 02115.) |
| Abstract | Intercellular adhesion molecule-1 (ICAM-1) on the surface of cultured umbilical vein and saphenous vein endothelial cells was upregulated between 2.5- and 40-fold by rIL-1, rTNF, LPS and rIFN gamma corresponding to up to 5 X 10(6) sites/cell. Endothelial cell ICAM-1 was a single band of 90 kD in SDS-PAGE. Purified endothelial cell ICAM- 1 reconstituted into liposomes and bound to plastic was an excellent substrate for both JY B lymphoblastoid cell and T lymphoblast adhesion. Adhesion to endothelial cell ICAM-1 in planar membranes was blocked completely by monoclonal antibodies to lymphocyte function associated antigen-1 (LFA-1) or ICAM-1. Adhesion to artificial membranes was most sensitive to ICAM-1 density within the physiological range found on resting and stimulated endothelial cells. Adhesion of JY B lymphoblastoid cells, normal and genetically LFA-1 deficient T lymphoblasts and resting peripheral blood lymphocytes to endothelial cell monolayers was also assayed. In summary, LFA-1 dependent (60-90% of total adhesion) and LFA-1-independent basal adhesion was observed and the use of both adhesion pathways by different interacting cell pairs was increased by monokine or lipopolysaccharide stimulation of endothelial cells. The LFA-1-dependent adhesion could be further subdivided into an LFA-1/ICAM-1-dependent component which was increased by cytokines and a basal LFA-1-dependent, ICAM-1-independent component which did not appear to be affected by cytokines. We conclude that ICAM- 1 is a regulated ligand for lymphocyte-endothelial cell adhesion, but at least two other major adhesion pathways exist. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 1 |
| Volume Number | 107 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 1988-07-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Antigens, Surface Endothelium, Vascular Cytology Lymphocytes Membrane Glycoproteins Metabolism Antibodies, Monoclonal Immunology B-Lymphocytes Cell Adhesion Cell Adhesion Molecules Cell Line Cells, Cultured Escherichia Coli Flow Cytometry Fluorescent Antibody Technique Interferon-gamma Pharmacology Lipopolysaccharides Lymphocyte Function-Associated Antigen-1 Radioimmunoassay Recombinant Proteins Saphenous Vein T-Lymphocytes Tumor Necrosis Factor-alpha Umbilical Veins Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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