NDLI: Recycling glycoproteins do not return to the cis-Golgi.

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Recycling glycoproteins do not return to the cis-Golgi.

Content Provider	Scilit
Author	Neefjes, Jacques Verkerk, J. M. Broxterman, H. J. Marel, G. A. Van Der Boom, J. H. Van Ploegh, H. L.
Copyright Year	1988
Description	Recycling of a number of glycoproteins along the site of action of mannosidase I (the distal endoplasmic reticulum/cis-Golgi) was followed in several different cell lines. Treatment of cells with 1-deoxymannojirimycin (dMM) produced high mannose oligosaccharides at positions otherwise occupied by complex-type oligosaccharides in these glycoproteins. Conversion of high-mannose-type oligosaccharides to complex oligosaccharides of proteins initially synthesized in the presence of dMM was used as a marker for recycling of glycoproteins along the site of action of dMM. In contrast to findings reported by Snider and Rogers (Snider, M. D., and O. C. Rogers. 1986. J. Cell Biol. 103:265-275), removal of dMM did not result in reconversion of high-mannose oligosaccharides to complex-type sugars, even after prolonged periods of culture. We conclude that surface glycoproteins do not recycle through the cis-medial Golgi elements.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2115183/pdf http://jcb.rupress.org/content/107/1/79.full.pdf
Ending Page	87
Page Count	9
Starting Page	79
DOI	10.1083/jcb.107.1.79
Journal	Journal of Cell Biology
Issue Number	1
Volume Number	107
Language	English
Publisher	Rockefeller University Press
Publisher Date	1988-07-01
Access Restriction	Open
Subject Keyword	Biochemistry and Molecular Biology Treatment Glycoproteins Recycling Oligosaccharides Dmm Golgi Mannose Rogers Snider Journal: Journal of Cell Biology (Vol- 107, Issue- 1)
Content Type	Text

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