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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Zakharenko, S. Popov, S. |
| Description | Author Affiliation: Zakharenko S ( Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, Illinois 60612, USA.) |
| Abstract | Nerve growth depends on the delivery of cell body–synthesized material to the growing neuronal processes. The cellular mechanisms that determine the topology of new membrane addition to the axon are not known. Here we describe a technique to visualize the transport and sites of exocytosis of cell body– derived vesicles in growing axons. We found that in Xenopus embryo neurons in culture, cell body–derived vesicles were rapidly transported all the way down to the growth cone region, where they fused with the plasma membrane. Suppression of microtubule (MT) dynamic instability did not interfere with the delivery of new membrane material to the growth cone region; however, the insertion of vesicles into the plasma membrane was dramatically inhibited. Local disassembly of MTs by focal application of nocodazole to the middle axonal segment resulted in the addition of new membrane at the site of drug application. Our results suggest that the local destabilization of axonal MTs is necessary and sufficient for the delivery of membrane material to specific neuronal sites. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 4 |
| Volume Number | 143 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 1998-11-16 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Axonal Transport Physiology Microtubules Metabolism Neurites Animals Antineoplastic Agents Pharmacology Antineoplastic Agents, Phytogenic Biological Transport Drug Effects Carbocyanines Cell Membrane Diffusion Exocytosis Fluorescent Dyes Lipid Metabolism Nocodazole Paclitaxel Staining And Labeling Synaptic Vesicles Vinblastine Xenopus Research Support, U.S. Gov't, P.H.S. Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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