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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Herrmann, B. Suzuki, K. Granzier, H. Centner, T. Gregorio, C. C. Kunke, K. Kolmerer, B. Obermayr, F. Labeit, S. Stier, G. Sorimachi, H. Trombitás, K. |
| Description | Author Affiliation: Gregorio CC ( Departments of Cell Biology and Anatomy, and Molecular and Cellular Biology, University of Arizona, Tucson, Arizona 85724, USA. gregorio@u.arizona.edu) |
| Abstract | Titin is a giant elastic protein in vertebrate striated muscles with an unprecedented molecular mass of 3–4 megadaltons. Single molecules of titin extend from the Z-line to the M-line. Here, we define the molecular layout of titin within the Z-line; the most $NH_{2}-terminal$ 30 kD of titin is located at the periphery of the Z-line at the border of the adjacent sarcomere, whereas the subsequent 60 kD of titin spans the entire width of the Z-line. In vitro binding studies reveal that mammalian titins have at least four potential binding sites for α-actinin within their Z-line spanning region. Titin filaments may specify Z-line width and internal structure by varying the length of their $NH_{2}-terminal$ overlap and number of α-actinin binding sites that serve to cross-link the titin and thin filaments. Furthermore, we demonstrate that the $NH_{2}-terminal$ titin Ig repeats Z1 and Z2 in the periphery of the Z-line bind to a novel 19-kD protein, referred to as titin-cap. Using dominant-negative approaches in cardiac myocytes, both the titin Z1-Z2 domains and titin-cap are shown to be required for the structural integrity of sarcomeres, suggesting that their interaction is critical in titin filament–regulated sarcomeric assembly. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 4 |
| Volume Number | 143 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 1998-11-16 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Muscle Proteins Chemistry Metabolism Protein Kinases Sarcomeres Actinin Amino Acid Sequence Animals Cells, Cultured Chick Embryo Connectin Gene Expression Physiology Membrane Proteins Genetics Microscopy, Immunoelectron Molecular Sequence Data Muscle Fibers, Skeletal Cytology Ultrastructure Muscle, Skeletal Myocardium Myofibrils Protein Structure, Tertiary Transcription, Genetic Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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