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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Johannes, Ludger Tenza, Danièle Tang, Bor Luen Antony, Claude Mallard, Frédéric Saint-pol, Agnès Hong, Wanjin Goud, Bruno Galli, Thierry Yue, Xu |
| Description | Author Affiliation: Mallard F ( UMR144 Curie/CNRS, Institut Curie, F-75248 Paris Cedex 05, France.) |
| Abstract | The molecular mechanisms underlying early/recycling endosomes-to-TGN transport are still not understood. We identified interactions between the TGN-localized putative t-SNAREs syntaxin 6, syntaxin 16, and Vti1a, and two early/recycling endosomal v-SNAREs, VAMP3/cellubrevin, and VAMP4. Using a novel permeabilized cell system, these proteins were functionally implicated in the post-Golgi retrograde transport step. The function of Rab6a' was also required, whereas its closely related isoform, Rab6a, has previously been implicated in Golgi-to-endoplasmic reticulum transport. Thus, our study shows that membrane exchange between the early endocytic and the biosynthetic/secretory pathways involves specific components of the Rab and SNARE machinery, and suggests that retrograde transport between early/recycling endosomes and the endoplasmic reticulum is critically dependent on the sequential action of two members of the Rab6 subfamily. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 4 |
| Volume Number | 156 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 2002-02-18 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Carrier Proteins Metabolism Endosomes Membrane Proteins Vesicular Transport Proteins Rab GTP-Binding Proteins Trans-Golgi Network Animals Biological Transport, Active CHO Cells Cricetinae HeLa Cells Protein Isoforms Qa-SNARE Proteins Qb-SNARE Proteins SNARE Proteins Shiga Toxins Syntaxin 16 Vesicle-Associated Membrane Protein 3 Research Support, Non-U.S. Gov't Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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