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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Spann, Timothy P. Goldman, Robert D. Wang, Chen Huang, Sui Goldman, Anne E. |
| Description | Author Affiliation: Spann TP ( Department of Cell and Molecular Biology, Northwestern University Medical School, Chicago, IL 60611, USA.) |
| Abstract | RTegulation of gene activity is mediated by alterations in chromatin organization. In addition, chromatin organization may be governed in part by interactions with structural components of the nucleus. The nuclear lamins comprise the lamina and a variety of nucleoplasmic assemblies that together are major structural components of the nucleus. Furthermore, lamins and lamin-associated proteins have been reported to bind chromatin. These observations suggest that the nuclear lamins may be involved in the regulation of gene activity. In this report, we test this possibility by disrupting the normal organization of nuclear lamins with a dominant negative lamin mutant lacking the $NH_{2}-terminal$ domain. We find that this disruption inhibits RNA polymerase II activity in both mammalian cells and transcriptionally active embryonic nuclei from Xenopus laevis. The inhibition appears to be specific for polymerase II as disruption of lamin organization does not detectably inhibit RNA polymerases I and III. Furthermore, immunofluorescence observations indicate that this selective inhibition of polymerase II–dependent transcription involves the TATA binding protein, a component of the basal transcription factor TFIID. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 4 |
| Volume Number | 156 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 2002-02-18 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Nuclear Proteins Metabolism RNA Polymerase II Antagonists & Inhibitors Transcription, Genetic 3T3 Cells Amanitins Pharmacology Animals Cell Line Cell Nucleus Cricetinae HeLa Cells Lamins Mice Genetics Nucleic Acid Synthesis Inhibitors Xenopus Laevis Research Support, U.S. Gov't, P.H.S. Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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