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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Johannes, Ludger Mitsuhashi, Hiroko Nishimoto-morita, Kirika Shin, Hye-won Kitamura, Masashi Zhang, Qian Nakayama, Kazuhisa |
| Description | Author Affiliation: Nishimoto-Morita K ( Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.) |
| Abstract | ARFRP1 and ARL1, which are both ARF-like small GTPases, are mammalian orthologs of yeast Arl3p and Arl1p, respectively. In yeast, Arl3p targeted to trans-Golgi network (TGN) membranes activates Arl1p, and the activated Arl1p in turn recruits a GRIP domain-containing protein; this complex regulates retrograde transport to the TGN and anterograde transport from the TGN. In the present study, using RNA interference-mediated knockdown of ARFRP1 and ARL1, we have examined whether the orthologs of Arl3p-Arl1p-GRIP story serve similar functions in mammalian cells. However, we have unexpectedly found differential roles of ARL1 and ARFRP1. Specifically, ARL1 and ARFRP1 regulate retrograde transport of Shiga toxin to the TGN and anterograde transport of VSVG from the TGN, respectively. Furthermore, we have obtained evidence suggesting that a SNARE complex containing Vti1a, syntaxin 6, and syntaxin 16 is involved in Shiga toxin transport downstream of ARL1. |
| ISSN | 00219258 |
| e-ISSN | 1083351X |
| Journal | Journal of Biological Chemistry |
| Issue Number | 16 |
| Volume Number | 284 |
| Language | English |
| Publisher | American Society for Biochemistry and Molecular Biology (United States) |
| Publisher Date | 2009-04-17 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | ADP-Ribosylation Factors Metabolism Endosomes Intracellular Membranes Membrane Proteins Trans-Golgi Network Genetics Animals Biological Transport Physiology HeLa Cells Membrane Glycoproteins Qa-SNARE Proteins Qb-SNARE Proteins RNA Interference RNA, Small Interfering Recombinant Fusion Proteins SNARE Proteins Shiga Toxin Viral Envelope Proteins Research Support, Non-U.S. Gov't Biochemistry Molecular Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Biochemistry Molecular Biology |
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