NDLI: Mitochondrial biogenesis, switching the sorting pathway of the intermembrane space receptor Mia40.

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Mitochondrial biogenesis, switching the sorting pathway of the intermembrane space receptor Mia40.

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Mitochondrial biogenesis, switching the sorting pathway of the intermembrane space receptor Mia40.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Chacinska, Agnieszka Schulze-specking, Agnes Pfanner, Nikolaus Müller, Judith M. Kutik, Stephan Guiard, Bernard Gabriel, Kipros
Description	Author Affiliation: Chacinska A ( Institut für Biochemie und Molekularbiologie, ZBMZ, Universität Freiburg, 79104 Freiburg, Germany.)
Abstract	Mitochondrial precursor proteins are directed into the intermembrane space via two different routes, the presequence pathway and the redox-dependent MIA pathway. The pathways were assumed to be independent and transport different proteins. We report that the intermembrane space receptor Mia40 can switch between both pathways. In fungi, Mia40 is synthesized as large protein with an N-terminal presequence, whereas in metazoans and plants, Mia40 consists only of the conserved C-terminal domain. Human MIA40 and the C-terminal domain of yeast Mia40 (termed Mia40(core)) rescued the viability of Mia40-deficient yeast independently of the presence of a presequence. Purified Mia40(core) was imported into mitochondria via the MIA pathway. With cells expressing both full-length Mia40 and Mia40(core), we demonstrate that yeast Mia40 contains dual targeting information, directing the large precursor onto the presequence pathway and the smaller Mia40(core) onto the MIA pathway, raising interesting implications for the evolution of mitochondrial protein sorting.
ISSN	00219258
e-ISSN	1083351X
Journal	Journal of Biological Chemistry
Issue Number	44
Volume Number	283
Language	English
Publisher	American Society for Biochemistry and Molecular Biology (United States)
Publisher Date	2008-10-31
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Mitochondria Metabolism Mitochondrial Membrane Transport Proteins Chemistry Saccharomyces Cerevisiae Proteins Animals Membrane Potentials Mitochondrial Proteins Genetics Models, Biological Oxidation-Reduction Phylogeny Protein Structure, Tertiary Protein Transport Recombinant Proteins Saccharomyces Cerevisiae Temperature Research Support, Non-U.S. Gov't Biochemistry Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Molecular Biology

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