NDLI: Analysis of a membrane interacting region of herpes simplex virus type 1 glycoprotein H.

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Analysis of a membrane interacting region of herpes simplex virus type 1 glycoprotein H.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Galdiero, Stefania Pedone, Carlo Isernia, Carla Vitiello, Mariateresa Galdiero, Massimiliano Raiola, Luca Falanga, Annarita Browne, Helena Fattorusso, Roberto
Description	Author Affiliation: Galdiero S ( Department of Biological Sciences, Division of Biostructures, University of Naples Federico II, Via Mezzocannone 16, 80134, Napoli, Italy.)
Abstract	Glycoprotein H (gH) of herpes simplex virus type I (HSV-1) is involved in the complex mechanism of membrane fusion of the viral envelope with the host cell. Membrane interacting regions and potential fusion peptides have been identified in HSV-1 gH as well as glycoprotein B (gB). Because of the complex fusion mechanism of HSV-1, which requires four viral glycoproteins, and because there are only structural data for gB and glycoprotein D, many questions regarding the mechanism by which HSV-1 fuses its envelope with the host cell membrane remain unresolved. Previous studies have shown that peptides derived from certain regions of gH have the potential to interact with membranes, and based on these findings we have generated a set of peptides containing mutations in one of these domains, gH-(626-644), to investigate further the functional role of this region. Using a combination of biochemical, spectroscopic, and nuclear magnetic resonance techniques, we showed that the alpha-helical nature of this stretch of amino acids in gH is important for membrane interaction and that the aromatic residues, tryptophan and tyrosine, are critical for induction of fusion.
ISSN	00219258
e-ISSN	1083351X
Journal	Journal of Biological Chemistry
Issue Number	44
Volume Number	283
Language	English
Publisher	American Society for Biochemistry and Molecular Biology (United States)
Publisher Date	2008-10-31
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Gene Expression Regulation, Viral Mutation Viral Envelope Proteins Metabolism Acrylamide Chemistry Amino Acid Sequence Amino Acids Circular Dichroism Kinetics Magnetic Resonance Spectroscopy Models, Biological Molecular Sequence Data Peptide Hydrolases Protein Structure, Secondary Tryptophan Biochemistry Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Molecular Biology

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