NDLI: Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils.

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Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Gijón, Miguel A. Murphy, Robert C. Voelker, Dennis R. Riekhof, Wayne R. Zarini, Simona
Description	Author Affiliation: Gijón MA ( Department of Pharmacology, University of Colorado Denver, Aurora, Colorado 80045, USA.)
Abstract	The cycle of deacylation and reacylation of phospholipids plays a critical role in regulating availability of arachidonic acid for eicosanoid production. The major yeast lysophospholipid acyltransferase, Ale1p, is related to mammalian membrane-bound O-acyltransferase (MBOAT) proteins. We expressed four human MBOATs in yeast strains lacking Ale1p and studied their acyl-CoA and lysophospholipid specificities using novel mass spectrometry-based enzyme assays. MBOAT1 is a lysophosphatidylserine (lyso-PS) acyltransferase with preference for oleoyl-CoA. MBOAT2 also prefers oleoyl-CoA, using lysophosphatidic acid and lysophosphatidylethanolamine as acyl acceptors. MBOAT5 prefers lysophosphatidylcholine and lyso-PS to incorporate linoleoyl and arachidonoyl chains. MBOAT7 is a lysophosphatidylinositol acyltransferase with remarkable specificity for arachidonoyl-CoA. MBOAT5 and MBOAT7 are particularly susceptible to inhibition by thimerosal. Human neutrophils express mRNA for these four enzymes, and neutrophil microsomes incorporate arachidonoyl chains into phosphatidylinositol, phosphatidylcholine, PS, and phosphatidylethanolamine in a thimerosal-sensitive manner. These results strongly implicate MBOAT5 and MBOAT7 in arachidonate recycling, thus regulating free arachidonic acid levels and leukotriene synthesis in neutrophils.
ISSN	00219258
e-ISSN	1083351X
Journal	Journal of Biological Chemistry
Issue Number	44
Volume Number	283
Language	English
Publisher	American Society for Biochemistry and Molecular Biology (United States)
Publisher Date	2008-10-31
Publisher Place	United States
Access Restriction	Open
Subject Keyword	1-Acylglycerophosphocholine O-Acyltransferase Metabolism Arachidonic Acid Neutrophils Acetyltransferases Cloning, Molecular Inflammation Mass Spectrometry Membrane Proteins Models, Biological Phospholipids Chemistry RNA, Messenger Substrate Specificity Thimerosal Pharmacology Time Factors Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Biochemistry Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Molecular Biology

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