NDLI: The role of amyloid precursor protein processing by BACE1, the beta-secretase, in Alzheimer disease pathophysiology.

Please wait, while we are loading the content...

Year: 2017 Volume: 292

Year: 2016 Volume: 291

Year: 2015 Volume: 290

Year: 2014 Volume: 289

Year: 2013 Volume: 288

Year: 2012 Volume: 287

Year: 2011 Volume: 286

Year: 2010 Volume: 285

Year: 2009 Volume: 284

Year: 2008 Volume: 283

Year: 2008 Volume: 283 Issue: 52

Year: 2008 Volume: 283 Issue: 51

Year: 2008 Volume: 283 Issue: 50

Year: 2008 Volume: 283 Issue: 49

Year: 2008 Volume: 283 Issue: 48

Year: 2008 Volume: 283 Issue: 47

Year: 2008 Volume: 283 Issue: 46

Year: 2008 Volume: 283 Issue: 45

Year: 2008 Volume: 283 Issue: 44

Identification of an evolutionarily conserved extracellular threonine residue critical for surface expression and its potential coupling of adjacent voltage-sensing and gating domains in voltage-gated potassium channels.

Thematic minireview series on the molecular basis of Alzheimer disease.

Amyloid precursor protein trafficking, processing, and function.

The role of amyloid precursor protein processing by BACE1, the beta-secretase, in Alzheimer disease pathophysiology.

Intramembrane proteolysis by gamma-secretase.

Regulation of amyloid beta-protein precursor by phosphorylation and protein interactions.

Rationally designed anti-HIV peptides containing multifunctional domains as molecule probes for studying the mechanisms of action of the first and second generation HIV fusion inhibitors.

Nonspecific Interaction of Prefibrillar Amyloid Aggregates with Glutamatergic Receptors Results in $Ca^{2+}$ Increase in Primary Neuronal Cells

Identification of $Mg^{2+}-dependent$ Neutral Sphingomyelinase 1 as a Mediator of Heat Stress-induced Ceramide Generation and Apoptosis

Analysis of a membrane interacting region of herpes simplex virus type 1 glycoprotein H.

Structural basis for a distinct catalytic mechanism in Trypanosoma brucei tryparedoxin peroxidase.

High affinity interaction between a bivalve C-type lectin and a biantennary complex-type N-glycan revealed by crystallography and microcalorimetry.

Replacement of a phenylalanine by a tyrosine in the active site confers fructose-6-phosphate aldolase activity to the transaldolase of Escherichia coli and human origin.

AML1/RUNX1 works as a negative regulator of c-Mpl in hematopoietic stem cells.

Substrate recognition of nitrogenase-like dark operative protochlorophyllide oxidoreductase from Prochlorococcus marinus.

Assembly of the yeast cell wall. Crh1p and Crh2p act as transglycosylases in vivo and in vitro.

Crystal structures of C4-dicarboxylate ligand complexes with sensor domains of histidine kinases DcuS and DctB.

The interaction between an acidic transcriptional activator and its inhibitor. The molecular basis of Gal4p recognition by Gal80p.

CDKL5 expression is modulated during neuronal development and its subcellular distribution is tightly regulated by the C-terminal tail.

Attenuation of IgE affinity for FcepsilonRI radically reduces the allergic response in vitro and in vivo.

Cell-specific regulation of PTX3 by glucocorticoid hormones in hematopoietic and nonhematopoietic cells.

Intramolecular activation mechanism of the Dictyostelium LRRK2 homolog Roco protein GbpC.

RNA Editing of Androgen Receptor Gene Transcripts in Prostate Cancer Cells

MicroRNA-221/222 confers tamoxifen resistance in breast cancer by targeting p27Kip1.

Activation-dependent hindrance of photoreceptor G protein diffusion by lipid microdomains.

Structure of human J-type co-chaperone HscB reveals a tetracysteine metal-binding domain.

Protein kinase C-related kinase and ROCK are required for thrombin-induced endothelial cell permeability downstream from Galpha12/13 and Galpha11/q.

Self-assembly of Glut4 storage vesicles during differentiation of 3T3-L1 adipocytes.

Impaired protein aggregate handling and clearance underlie the pathogenesis of p97/VCP-associated disease.

Functional Clustering of Mutations in the Dimer Interface of the Nucleotide Binding Folds of the Sulfonylurea Receptor

Structural, functional, and mutational analysis of the NblA protein provides insight into possible modes of interaction with the phycobilisome.

15-Deoxy-Δ(12,14)-prostaglandin $J_{2}$ Induces Vascular Endothelial Cell Apoptosis through the Sequential Activation of MAPKS and p53

Compartmentalization of Phosphatidylinositol 4,5-Bisphosphate Signaling Evidenced Using Targeted Phosphatases

A conserved Cys-loop receptor aspartate residue in the M3-M4 cytoplasmic loop is required for GABAA receptor assembly.

The AbetaCs of Abeta-cleaving proteases.

Structural classification of toxic amyloid oligomers.

Natural homolog of tRNA synthetase editing domain rescues conditional lethality caused by mistranslation.

Avian sarcoma virus and human immunodeficiency virus, type 1 use different subsets of ESCRT proteins to facilitate the budding process.

Hepatitis C Viral NS3-4A Protease Activity Is Enhanced by the NS3 $Helicase^{*S⃞}$

Three-dimensional reconstruction of human cystic fibrosis transmembrane conductance regulator chloride channel revealed an ellipsoidal structure with orifices beneath the putative transmembrane domain.

Multiple mechanisms contribute to Schizosaccharomyces pombe origin recognition complex-DNA interactions.

Functional adhesiveness of the CX3CL1 chemokine requires its aggregation. Role of the transmembrane domain.

The diversity of O-linked glycans expressed during Drosophila melanogaster development reflects stage- and tissue-specific requirements for cell signaling.

Delta Protein Kinase C Interacts with the d Subunit of the $F_{1}F_{0}$ ATPase in Neonatal Cardiac Myocytes Exposed to Hypoxia or Phorbol Ester: IMPLICATIONS FOR $F_{1}F_{0}$ ATPase REGULATION

Mutations M184V and Y115F in HIV-1 reverse transcriptase discriminate against 'nucleotide-competing reverse transcriptase inhibitors'.

Regulatory monoubiquitination of phosphoenolpyruvate carboxylase in germinating castor oil seeds.

Rac Regulates Its Effector Phospholipase $Cγ_{2}$ through Interaction with a Split Pleckstrin Homology $Domain^{*S⃞}$

Ciliary neurotrophic factor, cardiotrophin-like cytokine, and neuropoietin share a conserved binding site on the ciliary neurotrophic factor receptor alpha chain.

The cytochrome c maturation components CcmF, CcmH, and CcmI form a membrane-integral multisubunit heme ligation complex.

Expression of S100A6 in cardiac myocytes limits apoptosis induced by tumor necrosis factor-alpha.

KLF6 induces apoptosis in prostate cancer cells through up-regulation of ATF3.

Peptide and protein binding in the axial channel of Hsp104. Insights into the mechanism of protein unfolding.

Analysis of HSF4 Binding Regions Reveals Its Necessity for Gene Regulation during Development and Heat Shock Response in Mouse Lenses

Sgs1 RecQ helicase inhibits survival of Saccharomyces cerevisiae cells lacking telomerase and homologous recombination.

Interleukin-29 functions cooperatively with interferon to induce antiviral gene expression and inhibit hepatitis C virus replication.

Gly-Ala repeats induce position- and substrate-specific regulation of 26 S proteasome-dependent partial processing.

In vivo analysis of protein kinase B (PKB)/Akt regulation in DNA-PKcs-null mice reveals a role for PKB/Akt in DNA damage response and tumorigenesis.

Endoplasmic reticulum chaperone protein GRP-78 mediates endocytosis of dentin matrix protein 1.

Structural elucidation of the nonclassical secondary cell wall polysaccharide from Bacillus cereus ATCC 10987. Comparison with the polysaccharides from Bacillus anthracis and B. cereus type strain ATCC 14579 reveals both unique and common structural features.

Fate of Membrane-bound Reactants and Products during the Activation of Human Prothrombin by Prothrombinase

Dual activation of phospholipase C-epsilon by Rho and Ras GTPases.

Up-regulating Sphingosine 1-Phosphate Receptor-2 Signaling Impairs Chemotactic, Wound-healing, and Morphogenetic Responses in Senescent Endothelial Cells

Estrogen receptor (ER) beta or p53 attenuates ERalpha-mediated transcriptional activation on the BRCA2 promoter.

Ectodomain Lysines and Suramin Block of $P2X_{1}$ $Receptors^{*}$

Nck Adapters Are Involved in the Formation of Dorsal Ruffles, Cell Migration, and Rho Signaling Downstream of the Platelet-derived Growth Factor β Receptor

Peroxisome proliferator-activated receptor gamma down-regulates follistatin in intestinal epithelial cells through SP1.

Isoquinoline-1,3,4-trione derivatives inactivate caspase-3 by generation of reactive oxygen species.

Intramembrane Proteolysis of GXGD-type Aspartyl Proteases Is Slowed by a Familial Alzheimer Disease-like Mutation

Kinetic characterization of the protein Z-dependent protease inhibitor reaction with blood coagulation factor Xa.

Evolution of peptidase diversity.

Benzyl isothiocyanate targets mitochondrial respiratory chain to trigger reactive oxygen species-dependent apoptosis in human breast cancer cells.

Novel Mechanism for Suppression of Hyperpolarization-activated Cyclic Nucleotide-gated Pacemaker Channels by Receptor-like Tyrosine Phosphatase-α

Acylation of acylglycerols by acyl coenzyme A:diacylglycerol acyltransferase 1 (DGAT1). Functional importance of DGAT1 in the intestinal fat absorption.

Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils.

Foxo3a inhibits cardiomyocyte hypertrophy through transactivating catalase.

Goodpasture antigen-binding protein is a soluble exportable protein that interacts with type IV collagen. Identification of novel membrane-bound isoforms.

Structure of the Two Transmembrane $Cu^{+}$ Transport Sites of the $Cu^{+}-ATPases$

Regulation of interleukin-8 gene at a distinct site of its promoter by CCAAT enhancer-binding protein homologous protein in prostaglandin E2-treated human T cells.

Identification of proteins binding to E-Box/Ku86 sites and function of the tumor suppressor SAFB1 in transcriptional regulation of the human xanthine oxidoreductase gene.

A stopped flow transient kinetic analysis of substrate binding and catalysis in Escherichia coli D-3-phosphoglycerate dehydrogenase.

Direct allosteric regulation between the GAF domain and catalytic domain of photoreceptor phosphodiesterase PDE6.

Mitochondrial biogenesis, switching the sorting pathway of the intermembrane space receptor Mia40.

Fibrinogen-elongated gamma chain inhibits thrombin-induced platelet response, hindering the interaction with different receptors.

EFA6 facilitates the assembly of the tight junction by coordinating an Arf6-dependent and -independent pathway.

Direct interaction of nuclear liver X receptor-beta with ABCA1 modulates cholesterol efflux.

Year: 2008 Volume: 283 Issue: 43

Year: 2008 Volume: 283 Issue: 42

Year: 2008 Volume: 283 Issue: 41

Year: 2008 Volume: 283 Issue: 40

Year: 2008 Volume: 283 Issue: 39

Year: 2008 Volume: 283 Issue: 38

Year: 2008 Volume: 283 Issue: 37

Year: 2008 Volume: 283 Issue: 36

Year: 2008 Volume: 283 Issue: 35

Year: 2008 Volume: 283 Issue: 34

Year: 2008 Volume: 283 Issue: 33

Year: 2008 Volume: 283 Issue: 32

Year: 2008 Volume: 283 Issue: 31

Year: 2008 Volume: 283 Issue: 30

Year: 2008 Volume: 283 Issue: 29

Year: 2008 Volume: 283 Issue: 28

Year: 2008 Volume: 283 Issue: 27

Year: 2008 Volume: 283 Issue: 26

Year: 2008 Volume: 283 Issue: 25

Year: 2008 Volume: 283 Issue: 24

Year: 2008 Volume: 283 Issue: 23

Year: 2008 Volume: 283 Issue: 22

Year: 2008 Volume: 283 Issue: 21

Year: 2008 Volume: 283 Issue: 20

Year: 2008 Volume: 283 Issue: 19

Year: 2008 Volume: 283 Issue: 18

Year: 2008 Volume: 283 Issue: 17

Year: 2008 Volume: 283 Issue: 16

Year: 2008 Volume: 283 Issue: 15

Year: 2008 Volume: 283 Issue: 14

Year: 2008 Volume: 283 Issue: 13

Year: 2008 Volume: 283 Issue: 12

Year: 2008 Volume: 283 Issue: 11

Year: 2008 Volume: 283 Issue: 10

Year: 2008 Volume: 283 Issue: 9

Year: 2008 Volume: 283 Issue: 8

Year: 2008 Volume: 283 Issue: 7

Year: 2008 Volume: 283 Issue: 6

Year: 2008 Volume: 283 Issue: 5

Year: 2008 Volume: 283 Issue: 4

Year: 2008 Volume: 283 Issue: 3

Year: 2008 Volume: 283 Issue: 2

Year: 2008 Volume: 283 Issue: 1

Year: 2007 Volume: 282

Year: 2006 Volume: 281

Year: 2005 Volume: 280

Year: 2004 Volume: 279

Year: 2003 Volume: 278

Year: 2002 Volume: 277

Year: 2001 Volume: 276

Year: 2000 Volume: 275

Year: 1999 Volume: 274

Year: 1998 Volume: 273

Year: 1997 Volume: 272

Year: 1996 Volume: 271

Year: 1995 Volume: 270

Year: 1994 Volume: 269

Year: 1993 Volume: 268

Year: 1992 Volume: 267

Year: 1991 Volume: 266

Year: 1990 Volume: 265

Year: 1989 Volume: 264

Year: 1988 Volume: 263

Year: 1987 Volume: 262

Year: 1986 Volume: 261

Year: 1984 Volume: 259

Year: 1982 Volume: 257

Year: 1981 Volume: 256

Year: 1975 Volume: 250

The role of amyloid precursor protein processing by BACE1, the beta-secretase, in Alzheimer disease pathophysiology.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Cole, Sarah L. Vassar, Robert
Description	Author Affiliation: Cole SL ( Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA.)
Abstract	Amyloid plaques, composed of the amyloid beta-protein (Abeta), are hallmark neuropathological lesions in Alzheimer disease (AD) brain. Abeta fulfills a central role in AD pathogenesis, and reduction of Abeta levels should prove beneficial for AD treatment. Abeta generation is initiated by proteolysis of amyloid precursor protein (APP) by the beta-secretase enzyme BACE1. Bace1 knockout (Bace1(-/-)) mice have validated BACE1 as the authentic beta-secretase in vivo. BACE1 is essential for Abeta generation and represents a suitable drug target for AD therapy, especially because this enzyme is up-regulated in AD. However, although initial data indicated that Bace1(-/-) mice lack an overt phenotype, the BACE1-mediated processing of APP and other substrates may be important for specific biological processes. In this minireview, topics range from the initial identification of BACE1 to the fundamental knowledge gaps that remain in our understanding of this protease. We address pertinent questions such as putative causes of BACE1 elevation in AD and discuss why, nine years since the identification of BACE1, treatments that address the underlying pathological mechanisms of AD are still lacking.
ISSN	00219258
e-ISSN	1083351X
Journal	Journal of Biological Chemistry
Issue Number	44
Volume Number	283
Language	English
Publisher	American Society for Biochemistry and Molecular Biology (United States)
Publisher Date	2008-10-31
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Amyloid Precursor Protein Secretases Metabolism Amyloid Beta-Peptides Chemistry Aspartic Acid Endopeptidases Gene Expression Regulation Alzheimer Disease Genetics Therapy Animals Brain Mice Mice, Knockout Models, Biological Mutation Peptide Hydrolases Protein Structure, Tertiary Biochemistry Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Molecular Biology

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in