NDLI: Novel bifunctional natriuretic peptides as potential therapeutics.

Please wait, while we are loading the content...

Year: 2017 Volume: 292

Year: 2016 Volume: 291

Year: 2015 Volume: 290

Year: 2014 Volume: 289

Year: 2013 Volume: 288

Year: 2012 Volume: 287

Year: 2011 Volume: 286

Year: 2010 Volume: 285

Year: 2009 Volume: 284

Year: 2008 Volume: 283

Year: 2008 Volume: 283 Issue: 52

Year: 2008 Volume: 283 Issue: 51

Year: 2008 Volume: 283 Issue: 50

Discovery of cellular regulation by protein degradation.

Chemical Cross-linking Provides a Model of the γ-Secretase Complex Subunit Architecture and Evidence for Close Proximity of the C-terminal Fragment of Presenilin with APH-1

Actin Pedestal Formation by Enteropathogenic Escherichia coli Is Regulated by IQGAP1, Calcium, and Calmodulin

Tracking cell surface GABAB receptors using an alpha-bungarotoxin tag.

Ziram causes dopaminergic cell damage by inhibiting E1 ligase of the proteasome.

Genetic toggling of alkaline phosphatase folding reveals signal peptides for all major modes of transport across the inner membrane of bacteria.

Deciphering the Ligand-binding Sites in the Borrelia burgdorferi Complement Regulator-acquiring Surface Protein 2 Required for Interactions with the Human Immune Regulators Factor H and Factor H-like Protein $1^{*S⃞}$

Subunits of mitochondrial complex I exist as part of matrix- and membrane-associated subcomplexes in living cells.

Identification of an autoinhibitory mechanism that restricts C1 domain-mediated activation of the Rac-GAP alpha2-chimaerin.

Specificity of Interactions between mDia Isoforms and Rho Proteins

Structural basis of the migfilin-filamin interaction and competition with integrin beta tails.

Unchanged β-Adrenergic Stimulation of Cardiac L-type Calcium Channels in $Ca_{v}1.2$ Phosphorylation Site S1928A Mutant Mice

Isolation of intrinsically active (MEK-independent) variants of the ERK family of mitogen-activated protein (MAP) kinases.

The conserved third transmembrane segment of YidC contacts nascent Escherichia coli inner membrane proteins.

WDR5 interacts with mixed lineage leukemia (MLL) protein via the histone H3-binding pocket.

Cysteine S-nitrosylation protects protein-tyrosine phosphatase 1B against oxidation-induced permanent inactivation.

Role for 53BP1 Tudor domain recognition of p53 dimethylated at lysine 382 in DNA damage signaling.

Elevation of global O-GlcNAc levels in 3T3-L1 adipocytes by selective inhibition of O-GlcNAcase does not induce insulin resistance.

G4 resolvase 1 binds both DNA and RNA tetramolecular quadruplex with high affinity and is the major source of tetramolecular quadruplex G4-DNA and G4-RNA resolving activity in HeLa cell lysates.

Human Wrnip1 is localized in replication factories in a ubiquitin-binding zinc finger-dependent manner.

Mutations define cross-talk between the N-terminal nucleotide-binding domain and transmembrane helix-2 of the yeast multidrug transporter Pdr5: possible conservation of a signaling interface for coupling ATP hydrolysis to drug transport.

Kinetic characterization of lipid II-Ala:alanyl-tRNA ligase (MurN) from Streptococcus pneumoniae using semisynthetic aminoacyl-lipid II substrates.

Identification and characterization of small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase.

The p300 acetylase is critical for ligand-activated farnesoid X receptor (FXR) induction of SHP.

Abnormal patterns of lipoprotein lipase release into the plasma in GPIHBP1-deficient mice.

Endocytosis of the type III transforming growth factor-beta (TGF-beta) receptor through the clathrin-independent/lipid raft pathway regulates TGF-beta signaling and receptor down-regulation.

The structure of the glial cell line-derived neurotrophic factor-coreceptor complex: insights into RET signaling and heparin binding.

A catalytic role of heparin within the extracellular matrix.

Elevated Synaptic Activity Preconditions Neurons against an in Vitro Model of Ischemia

Localized Rho GTPase activation regulates RNA dynamics and compartmentalization in tumor cell protrusions.

Mechanical induction of an epithelial cell chymase associated with wound edge migration.

Mutational analysis reveals distinct features of the Nox4-p22 phox complex.

Active cystathionine beta-synthase can be expressed in heme-free systems in the presence of metal-substituted porphyrins or a chemical chaperone.

A novel germ cell-specific protein, SHIP1, forms a complex with chromatin remodeling activity during spermatogenesis.

Significance of NF-kappaB/GATA axis in tumor necrosis factor-alpha-induced expression of 6-sulfated cell recognition glycans in human T-lymphocytes.

Exploring the electron transfer properties of neuronal nitric-oxide synthase by reversal of the FMN redox potential.

Deactivation of Sphingosine Kinase 1 by Protein Phosphatase 2A

Fluorescence detection of a lipid-induced tetrameric intermediate in amyloid fibril formation by apolipoprotein C-II.

Discovery and validation of novel peptide agonists for G-protein-coupled receptors.

The chloroplast NAD(P)H dehydrogenase complex interacts with photosystem I in Arabidopsis.

Sequential action of ATP-dependent subunit conformational change and interaction between helical protrusions in the closure of the built-in lid of group II chaperonins.

Recruitment of the RNA helicase RHAU to stress granules via a unique RNA-binding domain.

Locally generated methylseleninic acid induces specific inactivation of protein kinase C isoenzymes: relevance to selenium-induced apoptosis in prostate cancer cells.

Formation of dopamine adducts derived from brain polyunsaturated fatty acids: mechanism for Parkinson disease.

UV radiation regulates Mi-2 through protein translation and stability.

Huntingtin regulates RE1-silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF) nuclear trafficking indirectly through a complex with REST/NRSF-interacting LIM domain protein (RILP) and dynactin p150 Glued.

Dexras1 interacts with FE65 to regulate FE65-amyloid precursor protein-dependent transcription.

Structure of human prostasin, a target for the regulation of hypertension.

Induction of protein kinase PKR-dependent activation of interferon regulatory factor 3 by vaccinia virus occurs through adapter IPS-1 signaling.

Ryanodine Receptor Activation by $Ca_{v}1.2$ Is Involved in Dendritic Cell Major Histocompatibility Complex Class II Surface Expression

The new beta-D-glucosidase in terpenoid-isoquinoline alkaloid biosynthesis in Psychotria ipecacuanha.

Monitoring light-induced structural changes of Channelrhodopsin-2 by UV-visible and Fourier transform infrared spectroscopy.

Lipin1 is a key factor for the maturation and maintenance of adipocytes in the regulatory network with CCAAT/enhancer-binding protein alpha and peroxisome proliferator-activated receptor gamma 2.

Mapping in vivo chromatin interactions in yeast suggests an extended chromatin fiber with regional variation in compaction.

Identification of Noncollagenous Sites Encoding Specific Interactions and Quaternary Assembly of α3α4α5(IV) Collagen: IMPLICATIONS FOR ALPORT GENE THERAPY

Extreme substrate promiscuity of the Neisseria oligosaccharyl transferase involved in protein O-glycosylation.

Prion protein amyloid formation under native-like conditions involves refolding of the C-terminal alpha-helical domain.

Watching the native supramolecular architecture of photosynthetic membrane in red algae: topography of phycobilisomes and their crowding, diverse distribution patterns.

The Protonation State of the Cross-linked Tyrosine during the Catalytic Cycle of Cytochrome c Oxidase

The fungal phytochrome FphA from Aspergillus nidulans.

The putative aminophospholipid translocases, DNF1 and DNF2, are not required for 7-nitrobenz-2-oxa-1,3-diazol-4-yl-phosphatidylserine flip across the plasma membrane of Saccharomyces cerevisiae.

Calcium-independent phospholipase A2 (iPLA2 beta)-mediated ceramide generation plays a key role in the cross-talk between the endoplasmic reticulum (ER) and mitochondria during ER stress-induced insulin-secreting cell apoptosis.

Identification and role of the homodimerization interface of the glycosylphosphatidylinositol-anchored membrane type 6 matrix metalloproteinase (MMP25).

Assembly of high order G alpha q-effector complexes with RGS proteins.

The Tumor Marker Human Placental Protein 11 Is an Endoribonuclease

Protein kinase A regulates 3-phosphatidylinositide dynamics during platelet-derived growth factor-induced membrane ruffling and chemotaxis.

Alix and ALG-2 are involved in tumor necrosis factor receptor 1-induced cell death.

C/EBP homology protein (CHOP) interacts with activating transcription factor 4 (ATF4) and negatively regulates the stress-dependent induction of the asparagine synthetase gene.

Novel bifunctional natriuretic peptides as potential therapeutics.

The low density lipoprotein receptor-related protein 1 mediates uptake of amyloid beta peptides in an in vitro model of the blood-brain barrier cells.

Unbiased screening for transcriptional targets of ZKSCAN3 identifies integrin beta 4 and vascular endothelial growth factor as downstream targets.

S-Nitrosylated Human Serum Albumin-mediated Cytoprotective Activity Is Enhanced by Fatty Acid $Binding^{*}$

Constitutive activity of JNK2 alpha2 is dependent on a unique mechanism of MAPK activation.

Yin Yang 1 is a critical repressor of matrix metalloproteinase-9 expression in brain neurons.

Extracellular Nampt promotes macrophage survival via a nonenzymatic interleukin-6/STAT3 signaling mechanism.

Targeting artificial transcription factors to the utrophin A promoter: effects on dystrophic pathology and muscle function.

Role of intermonomer ionic bridges in the stabilization of the actin filament.

A Pair of Circularly Permutated PDZ Domains Control RseP, the S2P Family Intramembrane Protease of Escherichia coli

Differential dependence of hypoxia-inducible factors 1 alpha and 2 alpha on mTORC1 and mTORC2.

Structure and hemimethylated CpG binding of the SRA domain from human UHRF1.

Mechanism of radical-based catalysis in the reaction catalyzed by adenosylcobalamin-dependent ornithine 4,5-aminomutase.

Murine Protein Serine/Threonine Kinase 38 Activates Apoptosis Signal-regulating Kinase 1 via $Thr^{838}$ Phosphorylation

A Novel Protein Domain Induces High Affinity Selenocysteine Insertion Sequence Binding and Elongation Factor Recruitment

RalA functions as an indispensable signal mediator for the nutrient-sensing system.

Regulation of cyclin D1 and Wnt10b gene expression by cAMP-responsive element-binding protein during early adipogenesis involves differential promoter methylation.

Year: 2008 Volume: 283 Issue: 49

Year: 2008 Volume: 283 Issue: 48

Year: 2008 Volume: 283 Issue: 47

Year: 2008 Volume: 283 Issue: 46

Year: 2008 Volume: 283 Issue: 45

Year: 2008 Volume: 283 Issue: 44

Year: 2008 Volume: 283 Issue: 43

Year: 2008 Volume: 283 Issue: 42

Year: 2008 Volume: 283 Issue: 41

Year: 2008 Volume: 283 Issue: 40

Year: 2008 Volume: 283 Issue: 39

Year: 2008 Volume: 283 Issue: 38

Year: 2008 Volume: 283 Issue: 37

Year: 2008 Volume: 283 Issue: 36

Year: 2008 Volume: 283 Issue: 35

Year: 2008 Volume: 283 Issue: 34

Year: 2008 Volume: 283 Issue: 33

Year: 2008 Volume: 283 Issue: 32

Year: 2008 Volume: 283 Issue: 31

Year: 2008 Volume: 283 Issue: 30

Year: 2008 Volume: 283 Issue: 29

Year: 2008 Volume: 283 Issue: 28

Year: 2008 Volume: 283 Issue: 27

Year: 2008 Volume: 283 Issue: 26

Year: 2008 Volume: 283 Issue: 25

Year: 2008 Volume: 283 Issue: 24

Year: 2008 Volume: 283 Issue: 23

Year: 2008 Volume: 283 Issue: 22

Year: 2008 Volume: 283 Issue: 21

Year: 2008 Volume: 283 Issue: 20

Year: 2008 Volume: 283 Issue: 19

Year: 2008 Volume: 283 Issue: 18

Year: 2008 Volume: 283 Issue: 17

Year: 2008 Volume: 283 Issue: 16

Year: 2008 Volume: 283 Issue: 15

Year: 2008 Volume: 283 Issue: 14

Year: 2008 Volume: 283 Issue: 13

Year: 2008 Volume: 283 Issue: 12

Year: 2008 Volume: 283 Issue: 11

Year: 2008 Volume: 283 Issue: 10

Year: 2008 Volume: 283 Issue: 9

Year: 2008 Volume: 283 Issue: 8

Year: 2008 Volume: 283 Issue: 7

Year: 2008 Volume: 283 Issue: 6

Year: 2008 Volume: 283 Issue: 5

Year: 2008 Volume: 283 Issue: 4

Year: 2008 Volume: 283 Issue: 3

Year: 2008 Volume: 283 Issue: 2

Year: 2008 Volume: 283 Issue: 1

Year: 2007 Volume: 282

Year: 2006 Volume: 281

Year: 2005 Volume: 280

Year: 2004 Volume: 279

Year: 2003 Volume: 278

Year: 2002 Volume: 277

Year: 2001 Volume: 276

Year: 2000 Volume: 275

Year: 1999 Volume: 274

Year: 1998 Volume: 273

Year: 1997 Volume: 272

Year: 1996 Volume: 271

Year: 1995 Volume: 270

Year: 1994 Volume: 269

Year: 1993 Volume: 268

Year: 1992 Volume: 267

Year: 1991 Volume: 266

Year: 1990 Volume: 265

Year: 1989 Volume: 264

Year: 1988 Volume: 263

Year: 1987 Volume: 262

Year: 1986 Volume: 261

Year: 1984 Volume: 259

Year: 1982 Volume: 257

Year: 1981 Volume: 256

Year: 1975 Volume: 250

Novel bifunctional natriuretic peptides as potential therapeutics.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Dickey, Deborah M. Burnett, John C. Potter, Lincoln R.
Description	Author Affiliation: Dickey DM ( Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, USA.)
Abstract	Synthetic atrial natriuretic peptide (carperitide) and B-type natriuretic peptide (BNP; nesiritide) are used to treat congestive heart failure. However, despite beneficial cardiac unloading properties, reductions in renal perfusion pressures limit their clinical effectiveness. Recently, CD-NP, a chimeric peptide composed of C-type natriuretic peptide (CNP) fused to the C-terminal tail of Dendroaspis natriuretic peptide (DNP), was shown to be more glomerular filtration rate-enhancing than BNP in dogs. However, the molecular basis for the increased responsiveness was not determined. Here, we show that the DNP tail has a striking effect on CNP, converting it from a non-agonist to a partial agonist of natriuretic peptide receptor (NPR)-A while maintaining the ability to activate NPR-B. This effect is specific for human receptors because CD-NP was only a slightly better activator of rat NPR-A due to the promiscuous nature of CNP in this species. Interesting, the DNP tail alone had no effect on any NPR even though it is effective in vivo. To further increase the potency of CD-NP for NPR-A, we converted two different triplet sequences within the CNP ring to their corresponding residues in BNP. Both variants demonstrated increased affinity and full agonist activity for NPR-A, whereas one was as potent as any NPR-A activator known. In contrast to a previous report, we found that DNP binds the natriuretic peptide clearance receptor (NPR-C). However, none of the chimeric peptides bound NPR-C with significantly higher affinity than endogenous ligands. We suggest that bifunctional chimeric peptides represent a new generation of natriuretic peptide therapeutics.
ISSN	00219258
e-ISSN	1083351X
Journal	Journal of Biological Chemistry
Issue Number	50
Volume Number	283
Language	English
Publisher	American Society for Biochemistry and Molecular Biology (United States)
Publisher Date	2008-12-12
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Natriuretic Peptides Chemistry Amino Acid Sequence Animals Binding, Competitive Dose-Response Relationship, Drug Elapidae Metabolism Glomerular Filtration Rate Ligands Molecular Sequence Data Natriuretic Peptide, C-Type Peptides Protein Structure, Tertiary Recombinant Fusion Proteins Research Support, Non-U.S. Gov't Biochemistry Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Molecular Biology

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in