NDLI: Ryanodine Receptor Activation by $Ca_{v}1.2$ Is Involved in Dendritic Cell Major Histocompatibility Complex Class II Surface Expression

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Ryanodine Receptor Activation by $Ca_{v}1.2$ Is Involved in Dendritic Cell Major Histocompatibility Complex Class II Surface Expression

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Spagnoli, Giulio C. Vukcevic, Mirko Zorzato, Francesco Treves, Susan Iezzi, Giandomenica
Description	Author Affiliation: Vukcevic M ( Department of Anaesthesia, Basel University Hospital, 4031 Basel, Switzerland.)
Abstract	Dendritic cells express the skeletal muscle ryanodine receptor (RyR1), yet little is known concerning its physiological role and activation mechanism. Here we show that dendritic cells also express the Ca(v)1.2 subunit of the L-type Ca(2+) channel and that release of intracellular Ca(2+) via RyR1 depends on the presence of extracellular Ca(2+) and is sensitive to ryanodine and nifedipine. Interestingly, RyR1 activation causes a very rapid increase in expression of major histocompatibility complex II molecules on the surface of dendritic cells, an effect that is also observed upon incubation of mouse BM12 dendritic cells with transgenic T cells whose T cell receptor is specific for the I-A(bm12) protein. Based on the present results, we suggest that activation of the RyR1 signaling cascade may be important in the early stages of infection, providing the immune system with a rapid mechanism to initiate an early response, facilitating the presentation of antigens to T cells by dendritic cells before their full maturation.
ISSN	00219258
e-ISSN	1083351X
Journal	Journal of Biological Chemistry
Issue Number	50
Volume Number	283
Language	English
Publisher	American Society for Biochemistry and Molecular Biology (United States)
Publisher Date	2008-12-12
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Calcium Channels, L-Type Chemistry Gene Expression Regulation Ryanodine Receptor Calcium Release Channel Metabolism Animals Antigen Presentation Antigens, CD Biosynthesis Calcium Dendritic Cells Immunoglobulins Membrane Glycoproteins Membrane Potentials Mice Signal Transduction T-Lymphocytes Research Support, Non-U.S. Gov't Biochemistry Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Molecular Biology

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