NDLI: Quantifying factors that influence metal ion release in photocaged complexes using ZinCast derivatives

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Singh, Charlene V. Gwizdala, Celina Friss, Tracey R. Macdonald, John C. Burdette, Shawn C.
Description	Author Affiliation: Gwizdala C ( University of Connecticut, 55 North Eagleville Road, Storrs, CT 06269-3060, USA.)
Abstract	Two generations of nitrobenzhydrol-based photocages for $Zn^{2+}$ have been prepared and characterized. The first series includes the tridentate ZinCast-1 utilizes a bis-pyridin-2-ylmethyl-aniline ligand that forms a 5,5-chelate ring upon metal binding. The related photocages ZinCast-2 with a N-[2-(pyridine-2-yl)ethyl]-N-(pyridine-2-ylmethyl)aniline (5,6-chelate ring) and ZinCast-3 with a N,N-bis[2-(pyridine-2-yl)ethyl]aniline (6,6-chelate ring) were synthesized for comparative studies. The complexes formed by the ions $Cu^{2+},$ $Zn^{2+}$ and $Cd^{2+}$ with three ZinCast and their photoproducts (ZinUnc) were interrogated by UV-Vis spectroscopy. The studies indicate that ZinCast-1 forms complexes of the highest stability and ZinCast-3 exhibits the most significant changes in metal affinity upon uncaging. These results suggest that the changes in nitrogen atom donor ability as well as the initial complex stability must be considered to design a photocage with the desired properties. The composite results were used to design ZinCast-4 and ZinCast-5, the second generation photocages that incorporate an additional adjacent ether ligand into the $Zn^{2+}$ chelator.
ISSN	14779226
Issue Number	26
Volume Number	41
e-ISSN	13645447
Journal	Dalton Trans.
Language	English
Publisher	Royal Society of Chemistry
Publisher Date	2012-07-14
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Cadmium Chemistry Coordination Complexes Copper Zinc Chemical Synthesis Crystallography, X-Ray Ions Ligands Molecular Conformation Pyridines Spectrophotometry, Ultraviolet Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.
Content Type	Text
Resource Type	Article
Subject	Inorganic Chemistry

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