NDLI: Uniform magnesium silicate hollow spheres as high drug-loading nanocarriers for cancer therapy with low systemic toxicity

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wang, Baixiang Bi, Ming Meng, Weiyan Wang, Jingyun Ni, Yuxin Cai, Qing
Description	Author Affiliation: Wang B ( Department of Prosthodontics, School of Stomatology, Jilin University, Changchun, 130021, P. R. China. baixiangwang1@gmail.com)
Abstract	Resulting from their versatile functionality, nanomaterials with low systemic toxicity have offered high-performance diagnostic and therapeutic capabilities. Here, we designed and synthesized uniform magnesium silicate hollow spheres as high drug-loading nanocarriers for cancer therapy. Through a classical Stöber method and a hydrothermal process, well-defined $MgSiO_{3}$ hollow spheres were prepared in a facile route with inexpensive inhesion. Compared with routinely used mesoporous silica nanoparticles, our $MgSiO_{3}$ hollow spheres with larger void space and mesoporous shell endowed the structures with a much higher storage capacity of guest molecules (2140 mg DOX $g^{−1})$ and a much more sustained release of anticancer drugs. In detail, the release property and therapeutic efficacy of DOX-loaded nanoparticles were evaluated in vitro and in vivo. In vitro experiments revealed that these nanoparticles were mostly accumulated in lysosome, which facilitated continual drug release and efficient cancer cell destruction. We further demonstrated that these DOX-loaded nanoparticles could effectively suppress tumor growth compared to free DOX in vivo, as DOX-loaded-nanoparticle-treated mice survived over 15 days without obvious detectable tumor growth. Otherwise, long-term toxicity study was also evaluated, indicating their overall safety and great potential in biomedical applications.
ISSN	14779226
Issue Number	24
Volume Number	42
e-ISSN	13645447
Journal	Dalton Trans.
Language	English
Publisher	Royal Society of Chemistry
Publisher Date	2013-06-28
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Antineoplastic Agents Pharmacology Drug Carriers Chemistry Magnesium Silicates Nanoparticles Neoplasms Drug Therapy Animals Endocytosis Female Fluorescein-5-isothiocyanate Hemolysis Hep G2 Cells Humans Hydrogen-Ion Concentration Lysosomes Drug Effects Mice Mice, Inbred C57BL Microscopy, Electron, Scanning Methods Neoplasm Transplantation Particle Size Tetrazolium Salts Thiazoles Journal Article
Content Type	Text
Resource Type	Article
Subject	Inorganic Chemistry

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