NDLI: Nonlinear optical response and biological applications of a series of pyrimidine -based molecules for copper(II) ion probe

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhou, Hongping Li, Lin Yang, Jiaxiang Tian, Yupeng Zhang, Shengyi Zhang, Qiong Zhang, Man Liu, Zhaodi Wu, Jieying
Description	Author Affiliation: Zhang Q ( Department of Chemistry, Key Laboratory of Functional Inorganic Materials Chemistry of Anhui Province, Anhui University, Hefei 230039, P. R. China.)
Abstract	Biological metal detecting, small molecule probes bearing nonlinear optical (NLO) response provide powerful alternatives due to their favorable photophysical properties (e.g. excitation wavelength in the near-IR region), cell permeability (due to their size), and chemical structure flexibility. Here, we present a series of pyrimidine -based NLO biological metal probes, especially a novel copper specific one which taken into account of the small volume-scaled and low cost-scaled nonlinear optical response of TPP and $TPP–Cu^{2+}$ discussed in our present work. The photophysical properties of the probes were thoroughly investigated. $^{1}H$ NMR and theoretical computation prove the binding interaction between the probe and the copper ion, which supports the functions of the molecule as a fluorescence signaling unit showing strong fluorescence quenching upon copper metal ion binding. On the other hand, the two- photon absorption cross-section of the novel copper probe increased from 275 to 591 GM $(λ_{ex}$ = 830 nm) after interacting with copper ion. It was further demonstrated that the NLO response for the copper(II) ion probe could be used for biological copper detection in live cells.
ISSN	14779226
Issue Number	24
Volume Number	42
e-ISSN	13645447
Journal	Dalton Trans.
Language	English
Publisher	Royal Society of Chemistry
Publisher Date	2013-06-28
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Biosensing Techniques Methods Copper Chemistry Pyrimidines Computer Simulation Electrons Hep G2 Cells Humans Ions Magnetic Resonance Spectroscopy Metals Nonlinear Dynamics Optics And Photonics Spectrometry, Fluorescence Spectrophotometry, Ultraviolet Tetrazolium Salts Pharmacology Thiazoles Journal Article Research Support, Non-U.S. Gov't
Content Type	Text
Resource Type	Article
Subject	Inorganic Chemistry

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