NDLI: Reduction of some Pt(IV) complexes with biologically important sulfur-donor ligands

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Jovanovic, Snezana Petrovic, Biljana Bugarcic, Zivadin D. Van Eldik, Rudi
Description	Author Affiliation: Jovanovic S ( Department of Chemistry, Faculty of Science, University of Kragujevac, R. Domanovica 12, P. O. Box 60, 34000 Kragujevac, Serbia.)
Abstract	The reduction of the Pt(IV) complexes $[PtCl_{4}(bipy)],$ $[PtCl_{4}(dach)]$ and $[PtCl_{4}(en)]$ by glutathione (GSH), L-cysteine ( L-Cys ) and L-methionine ( L-Met ) was investigated by stopped-flow spectrophotometry at pH 2.0 (in 0.01 M perchloric acid ) and at pH 7.2 (in 25 mM Hepes buffer ). Kinetic measurements were performed under pseudo-first order conditions with an excess of the reducing agent . The order of the reactivity of the studied complexes was $[PtCl_{4}(bipy)]$ > $[PtCl_{4}(dach)]$ > $[PtCl_{4}(en)],$ and reactivity of investigated reducing agents followed the order GSH > L-Cys > L-Met . All the reactions between the selected Pt(IV) complexes and the sulfur donor biomolecules proceeded by a reductive elimination process that included nucleophilic attack by the reducing agent on one of the mutually trans-coordinated chloride ligands , which led to a two-electron transfer process. The final products of the redox reactions were the corresponding reduced Pt(II) complexes and the oxidized form of the reducing agents .
ISSN	14779226
Issue Number	24
Volume Number	42
e-ISSN	13645447
Journal	Dalton Trans.
Language	English
Publisher	Royal Society of Chemistry
Publisher Date	2013-06-28
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Organoplatinum Compounds Chemistry Platinum Sulfur Chlorides Cysteine Dose-Response Relationship, Drug Glutathione Metabolism Hydrogen-Ion Concentration Hydrolysis Kinetics Ligands Methionine Oxidation-Reduction Oxygen Spectrophotometry Methods Spectrophotometry, Ultraviolet Time Factors Journal Article Research Support, Non-U.S. Gov't
Content Type	Text
Resource Type	Article
Subject	Inorganic Chemistry

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