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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Tavares, Ana Paula Palha, Ana Agapito, Ana Cortez, Luísa |
| Description | Author Affiliation: Palha A ( Department of Endocrinology, Centro Hospitalar de Lisboa Central, Lisbon, Portugal.); Cortez L ( Department of Endocrinology, Centro Hospitalar de Lisboa Central, Lisbon, Portugal.); Tavares AP ( Department of Surgery, Centro Hospitalar Lisboa Central, Lisbon, Portugal, Centro Hospitalar de Lisboa Central, Lisboa, Lisboa, Portugal.); Agapito A ( Department of Endocrinology, Centro Hospitalar de Lisboa Central, Lisbon, Portugal.) |
| Abstract | Androgen-secreting ovarian tumours are extremely rare accounting for <5% of all ovarian neoplasms. They are more frequent in postmenopausal women and should be suspected in the case of a rapid onset of androgenic symptoms. We report 4 cases of postmenopausal women who presented with signs of virilisation. All patients revealed increased serum levels of testosterone, normal dehydroepiandrosterone-sulfate and negative pelvic ultrasound for adnexal masses. An androgen-secreting ovarian tumour was suspected and all of them were submitted to bilateral oophorectomy. Histology confirmed the diagnosis of Leydig cell tumours in 3 patients and mature teratoma in 1. A successful response to surgery, which includes a decline in serum androgen levels and signs of hyperandrogenism, was observed in our patients. This case series demonstrates that androgen-secreting ovarian neoplasms may not be detectable by imaging studies, but should be considered in the differential diagnosis of all postmenopausal women with signs of hyperandrogenism. |
| Journal | BMJ Case Reports |
| Volume Number | 2016 |
| e-ISSN | 1757790X |
| Language | English |
| Publisher | BMJ Publishing Group Ltd. |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
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