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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Pardo, José V. |
| Description | Author Affiliation: Pardo JV ( Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota, USA Minneapolis Veterans Health Care System, Minneapolis, Minnesota, USA.) |
| Abstract | The vagus nerve stimulation (VNS) device is used not only to treat refractory seizure disorders but also mood disorders; the latter indication received CE Mark approval in 2001 and Food and Drug Administration approval in 2005. Original estimates for the end of battery life (EOBL) were approximately 6-10â years. Many neuropsychiatric patients have or will soon face EOBL. A patient with severe, life-threatening, treatment-resistant bipolar disorder underwent 9â years of stable remission following 20â months of adjunctive VNS. The device ceased operation at EOBL. Because of logistical issues, re-initiation of VNS was delayed over several months. The patient relapsed with depression, mania and mixed states, and regained remission 17â months after device replacement. This case dictates prudence in managing stable patients in remission with VNS. If the device malfunctions, urgent surgical replacement is warranted with subsequent rapid titration to previous parameters as tolerated. Several months' delay may trigger relapse and prove difficult to re-establish remission. |
| Journal | BMJ Case Reports |
| Volume Number | 2016 |
| e-ISSN | 1757790X |
| Language | English |
| Publisher | BMJ Publishing Group Ltd. |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
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